In silico PASS analysis and determination of antimycobacterial, antifungal, and antioxidant efficacies of maslinic acid in an extract rich in pentacyclic triterpenoids
| Autor: | Shahbaz K Pathan, Prasad G. Jamkhande, Shailesh J Wadher |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Antioxidant Antifungal Agents medicine.drug_class medicine.medical_treatment Phytochemicals lcsh:QR1-502 Antitubercular Agents Aspergillus flavus Antimycobacterial lcsh:Microbiology Antioxidants 03 medical and health sciences chemistry.chemical_compound Antioxidant activity Maslinic acid medicine Ustilago Computer Simulation Antifungal activity biology Traditional medicine Aspergillus niger Biological activity Triterpenoids Ascorbic acid biology.organism_classification Antimicrobial PASS Triterpenes 030104 developmental biology Infectious Diseases Aspergillus Biochemistry chemistry Antimycobacterial activity |
| Zdroj: | International Journal of Mycobacteriology, Vol 5, Iss 4, Pp 417-425 (2016) |
| ISSN: | 2212-554X |
| Popis: | Objective/background Microbial infections such as tuberculosis is a major cause of mortality worldwide. Plant-derived phytochemicals have a long history of providing much-needed novel therapeutics. Triterpenoids are among the prominent phytochemicals that possess numerous biological activities. Among them is maslinic acid (MA), a biologically active olean-type pentacyclic triterpenoid. In search of a novel antimicrobial agent, we aimed to evaluate the antimicrobial potential of MA. Methods Antibacterial and antifungal activity was evaluated through the agar well diffusion method. Antitubercular activity was analysed through the agar well diffusion and disc diffusion methods, respectively. Antioxidant capacity was determined through assays for total antioxidant capacity, 2,2-diphenyl-1-picrylhydrazyl radical scavenging, hydrogen peroxide radical scavenging, and Fe 3+ reducing power. The program Prediction of Activity Spectra for Substances was used to calculate the possible biological activity of MA. Results MA showed dose-dependent antioxidant activity similar to that of ascorbic acid. It had no inhibitory effect on bacterial strains, but it had moderate activity against the fungi Aspergillus flavus and Ustilago maydis , with Aspergillus niger being the most sensitive to MA. MA also exhibited strong antimycobacterial activity. Probable antioxidant, antibacterial, and antifungal activity of MA based on software calculations are 0.479, 0.363 and 0.589 respectively. Conclusion This work provides scientific evidence of the antioxidant, antifungal, and antimycobacterial activities of MA, showing its potential application in the development of natural antioxidants and antimicrobial agents for the agro-food and pharmaceutical industries. |
| Databáze: | OpenAIRE |
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