The effects of vitamin-rich carbohydrate pretreatment on the surgical stress response and S-100β after splenectomy in elderly rats
| Autor: | Tiande Yang, Qiuyan Yang, Lei Zhao, Xueli Chen, Mei Zeng, Youbo Zuo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Aging Carbohydrate Surgical stress medicine.medical_treatment Splenectomy S100 Calcium Binding Protein beta Subunit lcsh:RD78.3-87.3 Beverages Rats Sprague-Dawley chemistry.chemical_compound Random Allocation Animal model Insulin resistance Anesthesiology Internal medicine medicine Dietary Carbohydrates Animals Pain Postoperative business.industry Insulin Surgical stress response Vitamins medicine.disease Inflammatory mediators S-100β Rats Anesthesiology and Pain Medicine Endocrinology Treatment Outcome chemistry lcsh:Anesthesiology Inflammation Mediators business Biomarkers Research Article |
| Zdroj: | BMC Anesthesiology BMC Anesthesiology, Vol 19, Iss 1, Pp 1-6 (2019) |
| ISSN: | 1471-2253 |
| Popis: | Background Preoperative oral carbohydrates has been suggested to attenuate insulin resistance and decrease postoperative complications. In this study, a vitamin-rich carbohydrate beverage was administered before surgery in an animal model to investigate its effects on the surgical stress response and S-100β levels. Methods Thirty aged male Sprague-Dawley rats were randomly assigned to three groups: control group (n = 6), fasting group (n = 12), and carbohydrate-treated group (CHO group, n = 12). Rats in the control group were not given any treatment. Rats in the fasting group received splenectomy after 12 h of fasting. In the CHO group, rats were given 5 ml of vitamin-rich carbohydrate by gavage 2 h before surgery. Fasting plasma glucose, insulin, insulin resistance (HOMA-IR index, IRI), the S-100β protein level, and the inflammatory mediators IL-1β, IL-6 and TNF-α were assessed after surgery (postoperative day (POD) 1 and 3). Results Postoperative insulin resistance was significantly greater in the fasting group than in the control and CHO group. The median plasma S-100β level was significantly higher in the fasting group than in the control and CHO groups on POD 1. The median plasma IL-1β level was significantly lower in the CHO group than in the fasting group on POD 1; however, no other differences in the concentrations of immunological biomarkers of stress were found between the fasting group and the CHO group. Conclusions Vitamin-rich carbohydrate pretreatment attenuated the metabolic aspect of the surgical stress response and decreased the level of plasma S-100β, which may decrease the risk of postoperative complications in elderly rats. |
| Databáze: | OpenAIRE |
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