A triple blind, randomised, placebo controlled, add-on trial to assess the efficacy and safety of dexmedetomidine in facilitation of general anaesthesia in patients undergoing elective spine surgery
| Autor: | Chanchal Kumar Dalai, Madhumita Ray, Amita Acharjee, Shah Newaz Ahmed |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
medicine.drug_class lcsh:R Analgesic dexmedetomidine lcsh:Medicine Placebo general anesthesia Fentanyl spine surgery Sedative Anesthesia adverse effects Medicine General anaesthesia Dexmedetomidine General Agricultural and Biological Sciences business Propofol Adverse effect medicine.drug |
| Zdroj: | Asian Journal of Medical Sciences, Vol 12, Iss 3, Pp 20-27 (2021) |
| ISSN: | 2091-0576 2467-9100 |
| Popis: | Background: Dexmedetomidine is a centrally acting sympatholytic drug acting as an agonist on alpha2 receptors. Of late, the drug has become popular in anaesthesia because of its sedative, analgesic and anti-adrenergic effects. Aims and Objectives: We conducted a single centre, randomised, placebo controlled, triple blinded add-on trial to assess the efficacy and safety of the drug as an adjuvant in general anaesthesia (GA) during elective spine surgery. Materials and Methods: Anaesthesia was induced and maintained using standard method in all the patients (N=60). Concomitantly, patients in the treatment arm (n=30) and control arm (n=30) were infused with dexmedetomidine and normal saline respectively. The anaesthetic sparing effect, hemodynamic stability, and adverse events of dexmedetomidine were assessed using pre-defined outcome parameters. Results: Anaesthetic Sparing Effect: Dexmedetomidine produced statistically significant reduction in the requirement of propofol and fentanyl during GA (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|