Docosahexaenoic Acid Is an Independent Predictor of All-Cause Mortality in Hemodialysis Patients
| Autor: | Hitoshi Hirata, Hitoshi Inagaki, Tomohito Hamazaki, Shigeki Sawazaki, Masahiro Kuroda, Kei Hamazaki, Yoshihiro Terashima, Shin Tomita, Miho Itomura, Hidekuni Inadera |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Docosahexaenoic Acids medicine.medical_treatment Independent predictor Gastroenterology Cohort Studies Renal Dialysis Internal medicine Fatty Acids Omega-3 medicine Humans Prospective Studies Prospective cohort study Stroke Aged Proportional Hazards Models Aged 80 and over chemistry.chemical_classification business.industry food and beverages Middle Aged medicine.disease Eicosapentaenoic acid chemistry Biochemistry Nephrology Docosahexaenoic acid Kidney Failure Chronic Female lipids (amino acids peptides and proteins) Hemodialysis business All cause mortality Polyunsaturated fatty acid |
| Zdroj: | American Journal of Nephrology. 33:105-110 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000322952 |
| Popis: | Background: Dietary n–3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid have been shown to reduce cardiovascular mortality. Patients on hemodialysis (HD) have a very high mortality from cardiovascular disease. Fish consumption reduces all-cause mortality in patients on HD. Moreover, n–3 PUFAs, especially DHA levels in red blood cells (RBCs), are associated with arteriosclerosis in patients on HD. The aim of this study was to determine whether DHA levels in RBCs predict the mortality of patients on HD in a prospective cohort study. Methods: A cohort of 176 patients (64.1 ± 12.0 (mean ± SD) years of age, 96 men and 80 women) under HD treatment was studied. The fatty acid composition of their RBCs was analyzed by gas chromatography. Results: During the study period of 5 years, 54 deaths occurred. After adjustment for 10 confounding factors, the Cox hazard ratio of all-cause mortality of the patients on HD in the highest DHA tertile (>8.1%, 15 deaths) was 0.43 (95% CI 0.21–0.88) compared with those patients in the lowest DHA tertile (Conclusion: The findings suggest that the level of DHA in RBCs could be an independent predictor of all-cause mortality in patients on HD. |
| Databáze: | OpenAIRE |
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