Proteomics pinpoints alterations in grade I meningiomas of male versus female patients
| Autor: | Denildo César Amaral Veríssimo, Paulo C. Carvalho, Janaína M. Silva, Renata M. Santos, Marlon D.M. Santos, Gustavo A. R. Passos, Luis A.B. Borba, Juliana de Saldanha da Gama Fischer, Sergio Luiz Sprengel, Helisa H. Wippel, Fábio C. S. Nogueira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Proteomics Pathology medicine.medical_specialty Proteome Biopsy Central nervous system lcsh:Medicine Datasets as Topic Article Meninges Sex Factors Biomarkers Tumor Meningeal Neoplasms medicine Humans lcsh:Science Shotgun proteomics Aged Cancer Aged 80 and over Multidisciplinary Proteomic Profile business.industry Incidence (epidemiology) lcsh:R Proteins Middle Aged medicine.anatomical_structure RNA splicing lcsh:Q Female Neoplasm Grading Meningioma business Grade I Meningioma Signal Transduction |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Meningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells of the meninges. Surgery is the first option of treatment, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Reports indicate many differences in meningiomas from male versus female patients; for example, incidence is higher in females, whereas males usually develop the malignant and more aggressive type. With this as motivation, we used shotgun proteomics to compare the proteomic profile of grade I meningioma biopsies of male and female patients. Our results listed several differentially abundant proteins between the two groups; some examples are S100-A4 and proteins involved in RNA splicing events. For males, we identified enriched pathways for cell-matrix organization and for females, pathways related to RNA transporting and processing. We believe our findings contribute to the understanding of the molecular differences between grade I meningiomas of female and male patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|