Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids
| Autor: | Paolo Tecilla, Irene Izzo, Ines Bruno, J. Buirey, F. De Riccardis, G. Della Sala, Massimo Tosolini, Mariacarmela Vaccaro, Rosaria Schettini, Chiara Costabile |
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| Přispěvatelé: | Schettini, R., Costabile, C., Della Sala, G., Buirey, J., Tosolini, M., Tecilla, P., Vaccaro, M. C., Bruno, I., De Riccardis, F., Izzo, I. |
| Rok vydání: | 2018 |
| Předmět: |
Supramolecular chemistry
cyclic peptoid ion transport Antineoplastic Agents 010402 general chemistry 01 natural sciences Biochemistry Peptoids Hydroxyproline chemistry.chemical_compound Biomimetic Materials Cell Line Tumor Humans Physical and Theoretical Chemistry Ion transporter Cell Proliferation Liposome 010405 organic chemistry Sodium Organic Chemistry Alkali metal Combinatorial chemistry Affinities 0104 chemical sciences Monomer chemistry Surface modification |
| Zdroj: | Organic & Biomolecular Chemistry. 16:6708-6717 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed "submonomer/monomer" approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines. |
| Databáze: | OpenAIRE |
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