Controlled and Targeted Drug Delivery by a UV-responsive Liposome for Overcoming Chemo-resistance in Non-Hodgkin Lymphoma
| Autor: | Cong Wu, Kun Guo, Ling Shu, Jing Hou, Li Zhang, Lixin Wei, Shiwei Guo, Xiaobo Man, Naping Zhao, Huafei Li |
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| Rok vydání: | 2014 |
| Předmět: |
Ultraviolet Rays
medicine.medical_treatment Enhanced permeability and retention effect Mice SCID Pharmacology Biochemistry Polyethylene Glycols Diynes Immunoglobulin Fab Fragments Drug Delivery Systems Cell Line Tumor Drug Discovery medicine Distribution (pharmacology) Animals Humans CD20 Chemotherapy Liposome Antibiotics Antineoplastic biology business.industry Lymphoma Non-Hodgkin Organic Chemistry Antigens CD20 Multiple drug resistance Targeted drug delivery Doxorubicin Delayed-Action Preparations Liposomes biology.protein Phosphatidylcholines Molecular Medicine Female business Rituximab Antibodies Immobilized Ex vivo |
| Zdroj: | Chemical biologydrug design. 86(4) |
| ISSN: | 1747-0285 |
| Popis: | Although chemotherapy plays a vital role in treating non-Hodgkin lymphomas, the clinical applications are limited because of intolerable side-effects and multidrug resistance at the beginning or during the course of therapy. In this study, we successfully fabricated a CD20-targeting immuno-liposome based on 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC-8,9PC), which can form intermolecular cross-linking through the diacetylenic group by ultraviolet irradiation. This immuno-liposome showed appropriate size distribution, well-defined regular spherical structure, favorable biocompatibility, high serum stability, and prolonged circulation time in blood vessels. The in and ex vivo experiments demonstrate enhanced tumor suppression abilities against both wild-type and resistant non-Hodgkin lymphomas for liposomal doxorubicin when compared with free drugs. The outstanding antitumor activities are attributed to the accumulation and retention of liposomal drugs in malignant tissues and cells, which are realized by the co-operation of active targeting via antibody-antigen reaction and passive targeting via enhanced permeability and retention effect. |
| Databáze: | OpenAIRE |
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