Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)
| Autor: | Paola Dazzan, Alice Egerton, Birte Glenthøj, Kyra-Verena Sendt, Brian V. Broberg, N.E.M. van Haren, Signe Düring, Gareth J. Barker, René S. Kahn, Lone Baandrup, Rocío Pérez-Iglesias, David J. Lythgoe, Philip McGuire, Egill Rostrup, Kate Merritt, Iris E. C. Sommer, James M. Stone |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Positive and Negative Syndrome Scale business.industry medicine.medical_treatment Thalamus Glutamate receptor medicine.disease Gastroenterology 030227 psychiatry Clinical trial 03 medical and health sciences Cellular and Molecular Neuroscience Psychiatry and Mental health 0302 clinical medicine medicine.anatomical_structure Schizophrenia Internal medicine Medicine Amisulpride business Antipsychotic Molecular Biology 030217 neurology & neurosurgery Anterior cingulate cortex medicine.drug |
| Zdroj: | Egerton, A, Broberg, B V, van Haren, N E M, Merritt, K S, Barker, G J, Lythgoe, D J, Perez-Iglesias, R, Baandrup, L, During, S, Sendt, K-V, Stone, J M, Rostrup, E, Sommer, I E C, Glenthøj, B, Kahn, R S, Dazzan, P & McGuire, P 2018, ' Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels : A multicentre 1 H-MRS study (OPTiMiSE) ', Molecular Psychiatry, vol. 23, pp. 2145–2155 . https://doi.org/10.1038/s41380-018-0082-9 |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-018-0082-9 |
| Popis: | Conventional antipsychotic medication is ineffective in around a third of patients with schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated whether response to antipsychotics is related to brain glutamate levels prior to treatment. Proton magnetic resonance spectroscopy was used to measure glutamate levels (Glu/Cr) in the anterior cingulate cortex (ACC) and in the thalamus in antipsychotic-naive or minimally medicated patients with first episode psychosis (FEP, n = 71) and healthy volunteers (n = 60), at three sites. Following scanning, patients were treated with amisulpride for 4 weeks (n = 65), then 1H-MRS was repeated (n = 46). Remission status was defined in terms of Positive and Negative Syndrome Scale for Schizophrenia (PANSS) scores. Higher levels of Glu/Cr in the ACC were associated with more severe symptoms at presentation and a lower likelihood of being in remission at 4 weeks (P |
| Databáze: | OpenAIRE |
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