Clinical approach in the management of oral chronic graft-versus-host disease (cGVHD) in a series of specialized medical centers
| Autor: | Nicole M. A. Blijlevens, Michael T. Brennan, Mark M. Schubert, Judith E. Raber-Durlacher, Tuomas Waltimo, Elvira M. P. Correa, Sharon Elad, Siri Beier Jensen, Deborah P. Saunders, Noam Yarom, Nancy Mouradian, Joel B. Epstein, Yehuda Zadik |
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| Přispěvatelé: | Oral and Maxillofacial Surgery, Orale Geneeskunde (OII, ACTA), MKA AMC (OII, ACTA), Parodontologie (OII, ACTA), Faculteit der Geneeskunde, Oral Medicine, Maxillofacial Surgery (AMC), Periodontology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
MEDLINE Graft vs Host Disease Dentistry Disease Hospitals Special SDG 3 - Good Health and Well-being Surveys and Questionnaires Internal medicine hemic and lymphatic diseases Biopsy medicine Humans Oral mucosa medicine.diagnostic_test business.industry Nursing research Cancer Middle Aged medicine.disease Tacrolimus medicine.anatomical_structure Graft-versus-host disease Oncology Chronic Disease Mouth Diseases business Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Supportive care in cancer, 23(6), 1615-1622. Springer Verlag Supportive Care in Cancer, 23(6), 1615-1622. Springer Verlag Elad, S, Jensen, S B, Raber-Durlacher, J E, Mouradian, N, Correa, E M P, Schubert, M M, Blijlevens, N M A, Epstein, J B, Saunders, D P, Waltimo, T, Yarom, N, Zadik, Y & Brennan, M T 2015, ' Clinical approach in the management of oral chronic graft-versus-host disease (cGVHD) in a series of specialized medical centers ', Supportive Care in Cancer, vol. 23, no. 6, pp. 1615-1622 . https://doi.org/10.1007/s00520-014-2503-x Supportive Care in Cancer, 23, 1615-22 Supportive Care in Cancer, 23, 6, pp. 1615-22 |
| ISSN: | 0941-4355 |
| DOI: | 10.1007/s00520-014-2503-x |
| Popis: | BackgroundThe oral cavity is frequently affected in chronic graft-versus-host disease (cGVHD), with variable clinical presentations. The literature on the effective management of patients suffering from oral cGVHD is limited.ObjectiveThe objective of this study was to assess the clinical approaches used in the diagnosis and treatment of cGVHD in a group of health-care providers specialized in the oral care of oncology patients. The secondary objective was to assess the level of implementation of the National Institutes of Health (NIH) guidelines for cGVHD patients.MethodsOne hundred twenty questionnaires were sent to the members of the Oral Care Study Group (OCSG) of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). The questionnaire included 50 questions about the responder’s demographics, level of exposure to cGVHD patients, diagnostic and evaluation methods in their practice, preferred treatment strategies for mucosal and salivary gland involvement, and preventive measures.ResultsTwelve responders, representing 12 sites, stated that they treat oral cGVHD patients on a regular basis. This fraction of responders was confirmed by another online survey. Eleven out of the 12 providers were dentists. Seventy-five percent of the providers did not use biopsy in order to diagnose oral cGVHD. The NIH scale for the clinical assessment was used sporadically. The first-line topical treatment for oral mucosal cGVHD was predominantly steroids (91.7 %), and the second preferred treatment was tacrolimus (41.7 %). The preferred treatment for hyposalivation was pilocarpine (41.7 %). The recommended frequency of oral cancer screening varied; half of the providers suggest a follow-up every 6 months.ConclusionsThe responses described the common practices for oral cGVHD in several specialized centers across the world. The choice of topical treatments was influenced by the availability of medications in the provider’s country. |
| Databáze: | OpenAIRE |
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