Alternate wiring of a KNOXI genetic network underlies differences in leaf development of A. thaliana and C. hirsuta
| Autor: | Peter Huijser, Miltos Tsiantis, Suvi K. Broholm, Daniela Vlad, Gemma Bilsborough, Carolyn Ohno, Marcus G. Heisler, Huw Jenkins, Rob M. Ewing, Angela Hay, Raffaele Dello Ioio, Michiel Kwantes, Patrick Laufs, Claudia Canales, Madlen I. Rast-Somssich |
|---|---|
| Přispěvatelé: | Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research (MPIPZ), Department of Plant Sciences, University of Oxford [Oxford], Università degli Studi Roma Tre, Centre for Biological Sciences (University of Southampton), University of Southampton, Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, European Molecular Biology Laboratory (EMBL) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0106 biological sciences
Cardamine hirsuta Arabidopsis thaliana [SDV]Life Sciences [q-bio] Arabidopsis Gene regulatory network KNOXI genes 01 natural sciences 03 medical and health sciences Gene Expression Regulation Plant Pleiotropy regulatory evolution pleiotropy [SDV.IDA]Life Sciences [q-bio]/Food engineering Genetics [SDV.BV]Life Sciences [q-bio]/Vegetal Biology Gene Regulatory Networks [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Gene Plant Proteins 030304 developmental biology Homeodomain Proteins 0303 health sciences biology Arabidopsis Proteins fungi CUP-SHAPED COTYLEDON food and beverages biology.organism_classification Plant Leaves MicroRNAs Cardamine Homeobox Corrigendum 010606 plant biology & botany Developmental Biology Research Paper |
| Zdroj: | Genes and Development 22 (29), 2391-2404. (2015) Genes and Development Genes and Development, Cold Spring Harbor Laboratory Press, 2015, 29 (22), pp.2391-2404. ⟨10.1101/gad.269050.115⟩ |
| ISSN: | 0890-9369 |
| Popis: | Two interrelated problems in biology are understanding the regulatory logic and predictability of morphological evolution. Here, we studied these problems by comparing Arabidopsis thaliana, which has simple leaves, and its relative, Cardamine hirsuta, which has dissected leaves comprising leaflets. By transferring genes between the two species, we provide evidence for an inverse relationship between the pleiotropy of SHOOTMERISTEMLESS (STM) and BREVIPEDICELLUS (BP) homeobox genes and their ability to modify leaf form. We further show that cis-regulatory divergence of BP results in two alternative configurations of the genetic networks controlling leaf development. In C. hirsuta, ChBP is repressed by the microRNA164A (MIR164A)/ChCUP-SHAPED COTYLEDON (ChCUC) module and ChASYMMETRIC LEAVES1 (ChAS1), thus creating cross-talk between MIR164A/CUC and AS1 that does not occur in A. thaliana. These different genetic architectures lead to divergent interactions of network components and growth regulation in each species. We suggest that certain regulatory genes with low pleiotropy are predisposed to readily integrate into or disengage from conserved genetic networks influencing organ geometry, thus rapidly altering their properties and contributing to morphological divergence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|