A bifunctional heterodimeric insect neuropeptide analog
| Autor: | G. M. Holman, G. M. Coast, Ronald J. Nachman, William F. Haddon |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Malpighian tubule system
Insecta media_common.quotation_subject Molecular Sequence Data Neuropeptide Cockroaches Oviducts Insect Malpighian Tubules Insect Control Biochemistry Pentapeptide repeat Gryllidae chemistry.chemical_compound House cricket Animals Amino Acid Sequence Bifunctional media_common Dose-Response Relationship Drug biology Neuropeptides fungi Biological activity biology.organism_classification Peptide Fragments chemistry Acheta Insect Hormones Digestive System |
| Zdroj: | International Journal of Peptide and Protein Research. 40:423-428 |
| ISSN: | 0367-8377 |
| DOI: | 10.1111/j.1399-3011.1992.tb00320.x |
| Popis: | The synthesis and biological activity of a bifunctional, heterodimeric insect neuropeptide analog are described. The heterodimer is composed of the C-terminal pentapeptide active core regions of the leucokinin/achetakinin and pyrokinin neuropeptide families linked via their N-terminal amino groups with a succinyl diacid moiety. Members of the leucokinin/achetakinin family can induce fluid secretion in malpighian tubules of the house cricket, Acheta domesticus, whereas the pyrokinins demonstrate activity in a cricket oviduct myotropic bioassay. No cross-activity is observed for the two neuropeptide families in these bioassays. However, the heterodimer elicits responses in both Acheta bioassays. Such a bifunctional analog may in future serve as a template for the design of stable, bifunctional pest insect control agents of greater efficiency. |
| Databáze: | OpenAIRE |
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