A new method for radiolabeling of Gelfoam particles with 99mTc
| Autor: | Dimitrios G. Spigos, Dan G. Pavel, Stephen M. Karesh, Walter S. Tan |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Technetium Tc 99m Pyrophosphate Technetium Tc 99m Medronate Dogs Sulfur colloid medicine Animals Radiology Nuclear Medicine and imaging Technetium Tc 99m Aggregated Albumin Serum Albumin Reaction conditions Radiation Diphosphonates Chemistry Technetium Pentetic Acid Embolization Therapeutic Gelatin Sponge Absorbable Surgery Nuclear Energy and Engineering Isotope Labeling Technetium Tc 99m Sulfur Colloid Technetium Tc 99m Pentetate Reagent Kits Diagnostic Tin Polyphosphates Sulfur Biomedical engineering |
| Zdroj: | The International Journal of Applied Radiation and Isotopes. 33:1415-1421 |
| ISSN: | 0020-708X |
| DOI: | 10.1016/0020-708x(82)90179-x |
| Popis: | Embolization of the spleen and other organs using Gelfoam has recently gained acceptance as a therapeutic procedure. A simple non-invasive determination of the placement of Gelfoam particles is needed and this requires labeling Gelfoam with radionuclides. We have developed a simple, reliable reproducible, and inexpensive method of labeling Gelfoam with 99mTc using commercial sulfur colloid kits. Optimal reaction conditions include room temperature incubation for 60 min at 12 rpm rotation. In vitro stability indicated no loss of 99mTc activity up to 3 h post labeling. Imaging of intra-arterially placed 99mTc Gelfoam at 1 h and 24 h in animals and humans has consistently produced well-defined images of the radioemboli. |
| Databáze: | OpenAIRE |
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