Evaluation of the Immune Response to Interferon Gamma Release Assay and Tuberculin Skin Test Among BCG Vaccinated Children in East of Egypt
| Autor: | Raghdaa Abdelaziz Ramadan, Alaa Ebrahim Zidan, Hosam Fathi El-Saadny, Nehad Ahmed Karam, Nahla Mohamed Abdelsamad, Ezzat Kamel Amin, Mohamed Beshir, Marwa Zakaria Mohamed |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Tuberculosis Interferon gamma release assay Observational Study Tuberculin Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine medicine Humans Interferon gamma 030212 general & internal medicine Child Developing Countries biology Tuberculin Test business.industry Infant General Medicine bacterial infections and mycoses biology.organism_classification medicine.disease Vaccination Cross-Sectional Studies Child Preschool Immunology BCG Vaccine Egypt Female Interferon-gamma Release Tests business BCG vaccine Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000003470 |
| Popis: | Bacille Calmette-Guérin vaccine (BCG) vaccination is used routinely in most of countries, especially developing one. The efficacy of the BCG vaccination generally decreases with time. The tuberculin skin test (TST) is a most popular diagnostic test for suspicion of tuberculosis (TB) in children till now, but it has many false positives. The interferon-gamma release assay (IGRA) is more specific than TST for detection of childhood TB, as it is more specific to Mycobacterium tuberculosis. Evaluate the interferon gamma response and TST reaction in BCG vaccinated children in east of Egypt. 150 children were included in the study aged 1 month to 12 years; the collected data from the children included, full history taking, clinical examination, examination for the presence or absence of BCG scar under direct light. All the children had performed TST, IGRA. TST was done for all studied group reveal 51.3% with size of reaction |
| Databáze: | OpenAIRE |
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