Chronic Myeloid Leukemia in Myasthenia Gravis after Long-Term Treatment with 6-Mercaptopurine
| Autor: | L. J. Endtz, J. Wanders, A. R. Wattendorff, J. J. Nijs, C. H. W. Leeksma |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Thymoma
Long term treatment medicine.medical_treatment Leukemogenic hemic and lymphatic diseases Myasthenia Gravis Chromosomes Human 21-22 and Y Internal Medicine medicine Humans neoplasms Immunosuppressive treatment Mercaptopurine business.industry Myeloid leukemia Middle Aged Thymectomy medicine.disease Myasthenia gravis Leukemia Myeloid Immunology Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 210:235-238 |
| ISSN: | 0001-6101 |
| Popis: | A woman with myasthenia gravis and a thymoma did not respond sufficiently to thymectomy. She was treated with 6-mercaptopurine. Withdrawal of this treatment was several times followed by an aggravation of myasthenic symptoms. After more than 12 1/2 years treatment she developed Ph1 -positive chronic myeloid leukemia (CML). No other case of CML following immunosuppressive treatment has been described. Because the therapeutic agent is potentially leukemogenic, the possibility cannot be definitely excluded that the development of CML is not a mere coincidence. |
| Databáze: | OpenAIRE |
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