4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Autor:	George Philip Lahm, Eric A. Benner, Daniel Cordova, Kathleen Joraski, Michael J. Mahaffey, Caleb William Holyoke, Ben K. Smith, Rejane M. Smith, Jeffrey Keith Long, My-Hahn Tong, Mark E. Schroeder, Thomas F. Pahutski, James D. Barry, Ty Wagerle, Ming Xu
Rok vydání:	2013
Předmět:	Insecticides Insecta Stereochemistry media_common.quotation_subject Clinical Biochemistry Pharmaceutical Science Insect Biochemistry 4-azolylphenyl isoxazoline Structure-Activity Relationship chemistry.chemical_compound Receptors GABA GABA metabolism Chloride Channels Drug Discovery Animals Structure–activity relationship Molecular Biology media_common Dose-Response Relationship Drug Molecular Structure GABAA receptor Aryl fungi Organic Chemistry Biological activity Isoxazoles chemistry Chloride channel Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 23:3001-3006
ISSN:	0960-894X
Popis:	Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79032c07cd410e045b848bd1c29425ee https://doi.org/10.1016/j.bmcl.2013.03.031 Zobrazit plný text záznamu Full Text from ScienceDirect