Synthesis of [1-11C]D-glucose and [1-11C]D-mannose from on-line produced [11C]nitromethane
| Autor: | Christer Halldin, Bengt Långström, Karl-Olof Schoeps, Sharon Stone-Elander |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy Nitromethane General Engineering Mannose Total synthesis Brain Nitroparaffins chemistry.chemical_compound Nef reaction Glucose Aldose chemistry D-Glucose Isotope Labeling Nitro Humans Indicators and Reagents Carbon Radioisotopes Methane Chromatography High Pressure Liquid Nuclear chemistry Methyl iodide Tomography Emission-Computed |
| Zdroj: | International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. 42(9) |
| ISSN: | 0883-2889 |
| Popis: | A method for the preparation of [1- 11 C] d -glucose ( III ) and [1- 11 C] d -mannose ( IV ) from [ 11 C]nitromethane is described. [ 11 C]Nitromethane was produced using the on-line method from [ 11 C]methyl iodide. The condensation of no-carrier-added or carrier-added [ 11 C]nitromethane with d -arabinose to form the intermediate epimeric [1- 11 C] d -nitro alcohols ( I and II ) was investigated under various conditions. Compounds I and II were converted to III and IV by the classical Nef reaction with IV as the major product [ ( IV )/( III ) = 3 1 − 4 1 ]. The isolated radiochemical yield of III and IV was 25–30% (based on [ 11 C]nitromethane and decay-corrected) and 14–17% (EOB) with a total synthesis time of 50 min, including HPLC-purification. Compounds III and IV were isolated using semi-preparative HPLC and the radiochemical purity was >97%. In a typical run, 1.5–2.0 mCi of III and 6–8 mCi of IV could be isolated (starting from 70–90 mCi [ 11 C]nitromethane). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|