Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar

Autor: Ramiandrasoa, Noromanana Sylvia, Ravoniarimbinina, Pascaline, Solofoniaina, Armand Rafalimanantsoa, Andrianjafy Rakotomanga, Iharilanto Patricia, Andrianarisoa, Samuel Hermas, Molia, Sophie, Fahrion, Anna Sophie, Donadeu, Meritxell, Rajaonatahina, Davidra, Ramiandrasoa, Noromanana, Id, Ravoniarimbinina, Solofoniaina, Armand, Patricia, Iharilanto, Rakotomangaid, Andrianjafy, Andrianarisoa, Samuel, Moliaid, Sophie, Labouche, Anne-Marie, Sophie, Anna, 5¤, Fahrion, Donadeuid, Meritxell, Abela-Ridder, Bernadette, Rajaonatahinaid, Davidra
Přispěvatelé: Ministère de la Santé Publique [Antananarivo, Madagascar], Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Faculty of Veterinary and Agricultural Science [Melbourne], University of Melbourne, Initiative for Neglected Animal Diseases (INAND), Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona (CHUJRA)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
observation
Swine
Cross-sectional study
[SDV]Life Sciences [q-bio]
Neurocysticercosis
RC955-962
Pilot Projects
Praziquantel
Geographical Locations
Feces
Medical Conditions
0302 clinical medicine
Porcin
Zoonoses
Arctic medicine. Tropical medicine
Taenia solium
Medicine and Health Sciences
Taeniasis
030212 general & internal medicine
Thérapeutique médicamenteuse
Child
Mammals
education.field_of_study
Pharmaceutics
Eukaryota
Cysticercosis
3. Good health
medicine.drug_formulation_ingredient
Infectious Diseases
Helminth Infections
Research Design
S50 - Santé humaine
Vertebrates
Mass Drug Administration
Public Health
Public aspects of medicine
RA1-1270
L72 - Organismes nuisibles des animaux
Research Article
Neglected Tropical Diseases
medicine.drug
Adult
Drug Administration
030231 tropical medicine
Population
conseil
Research and Analysis Methods
03 medical and health sciences
Adverse Reactions
Drug Therapy
Environmental health
parasitic diseases
Parasitic Diseases
Madagascar
medicine
Animals
Humans
Cysticercose
Mass drug administration
education
Pharmacology
business.industry
Organisms
Public Health
Environmental and Occupational Health
Biology and Life Sciences
Pilot Studies
Tropical Diseases
medicine.disease
Cross-Sectional Studies
Enquête pathologique
People and Places
Africa
Amniotes
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Zoology
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (9), ⟨10.1371/journal.pntd.0008653⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008653 (2020)
ISSN: 1935-2727
1935-2735
DOI: 10.1371/journal.pntd.0008653⟩
Popis: Taenia solium is endemic in Madagascar and presents a significant burden on the population and the health system. The parasite cycles through humans who host the adult tapeworm, and pigs that host the larval stages. Accidental infection of humans may occur with the larval stages which encyst in the nervous central system causing neurocysticercosis, a major cause of seizure disorders and a public health problem. One of the interventions to facilitate the control of the disease is mass drug administration (MDA) of the human population with taeniacide. Here we describe a pilot project conducted in Antanifotsy district of Madagascar from 2015 to 2017 where three annual rounds of MDA (praziquantel, 10mg/Kg) were undertaken in 52 villages. Changes in the prevalence of taeniasis were assessed before, during and after the treatments. A total of 221,308 treatments were given to all eligible people above 5 years of age representing a 95% coverage of the targeted population. No major adverse effects were notified related to the implementation of the MDA. The prevalence of taeniasis was measured using Kato-Katz and copro-antigen techniques. Analyses undertaken combining the results of the Kato-Katz with copro-antigen, or using the Kato-Katz results alone, showed that there was a significant reduction in taeniasis 4 months after the last MDA, but 12 months later (16 months after the last MDA) the taeniasis prevalence had returned to its original levels. Results of the pilot project emphasize the need of a multi-sectorial One-Health approach for the sustained control of T. solium.
Author summary The parasite Taenia solium causes neurocysticercosis in humans in its larval stage and is the main cause of seizure disorders in poor communities that keep pigs (the intermediate host). Diagnosis and treatment of neurocysticercosis remains beyond the reach of the general population in Madagascar. Prevention is therefore the most suitable strategy for combating this disease. Mass drug administration (MDA) is used to treat communities for several parasitic diseases such as schistosomiasis. Infection with the T. solium tapeworm in people can be treated with MDA using praziquantel. Here, we conducted a pilot project in Madagascar, giving over 220,000 treatments to people in 52 villages once per year, for 3 consecutive years. The effects on taeniasis seemed to be encouraging when assessed 4 months after finishing the treatment, but 16 months later, the parasite’s prevalence had returned to its original level. MDA was effective in providing temporary control of taeniasis, but parasite transmission was not interrupted. With respect to T. solium, this highlights the need of incorporating other interventions such as vaccination and medication in pigs, improved pig husbandry and meat inspection to tackle the whole cycle of the parasite.
Databáze: OpenAIRE
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