A rabbit model of fatal hypothyroidism mimicking “myxedema coma” established by microscopic total thyroidectomy
| Autor: | Yosuke Ono, Sachiko Ono, Masanori Fujita, Yuji Tanaka, Shoichi Tachibana, Sho Ogata |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Bradycardia medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Myxedema coma 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Severity of Illness Index Diagnosis Differential Xylazine 03 medical and health sciences 0302 clinical medicine Endocrinology Hypothyroidism Myxedema medicine Animals Humans Coma business.industry Thyroid Thyroidectomy medicine.disease Surgery Disease Models Animal Blood pressure medicine.anatomical_structure Heart failure Anesthesia Rabbits medicine.symptom business Microdissection medicine.drug |
| Zdroj: | Endocrine Journal. 63:523-532 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej16-0005 |
| Popis: | Myxedema coma (MC) is a life-threatening endocrine crisis caused by severe hypothyroidism. However, validated diagnostic criteria and treatment guidelines for MC have not been established owing to its rarity. Therefore, a valid animal model is required to investigate the pathologic and therapeutic aspects of MC. The aim of the present study was to establish an animal model of MC induced by total thyroidectomy. We utilized 14 male New Zealand White rabbits anesthetized via intramuscular ketamine and xylazine administration. A total of 7 rabbits were completely thyroidectomized under a surgical microscope (thyroidectomized group) and the remainder underwent sham operations (control group). The animals in both groups were monitored without thyroid hormone replacement for 15 weeks. Pulse rate, blood pressure, body temperature, and electrocardiograms (ECG) were recorded and blood samples were taken from the jugular vein immediately prior to the thyroidectomy and 2 and 4 weeks after surgery. The thyroidectomized rabbits showed a marked reduction of serum thyroxine levels at 4 weeks after the surgical procedure vs. controls (0.50±0.10 vs. 3.32±0.68 μg/dL, p |
| Databáze: | OpenAIRE |
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