Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes

Autor: Nick Lane, Robert M. Seymour, Andrew Pomiankowski, Zena Hadjivasiliou
Rok vydání: 2013
Předmět:
0106 biological sciences
Mating type
Mitochondrial DNA
Heredity
Population
Genetic Fitness
Uniparental inheritance
Biology
medicine.disease_cause
010603 evolutionary biology
01 natural sciences
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
selfish conflict
medicine
sexes
Selection
Genetic
education
Research Articles
030304 developmental biology
General Environmental Science
Cell Nucleus
mitonuclear coadaptation
Genetics
0303 health sciences
education.field_of_study
Models
Genetic
General Immunology and Microbiology
Reproduction
Inheritance (genetic algorithm)
Eukaryota
General Medicine
Biological Evolution
mitochondria
Genes
Mitochondrial
mating types
Evolutionary biology
Mutation
Mutation (genetic algorithm)
uniparental inheritance
General Agricultural and Biological Sciences
Zdroj: Proceedings of the Royal Society B: Biological Sciences
ISSN: 1471-2954
0962-8452
DOI: 10.1098/rspb.2013.1920
Popis: The uniparental inheritance (UPI) of mitochondria is thought to explain the evolution of two mating types or even true sexes with anisogametes. However, the exact role of UPI is not clearly understood. Here, we develop a new model, which considers the spread of UPI mutants within a biparental inheritance (BPI) population. Our model explicitly considers mitochondrial mutation and selection in parallel with the spread of UPI mutants and self-incompatible mating types. In line with earlier work, we find that UPI improves fitness under mitochondrial mutation accumulation, selfish conflict and mitonuclear coadaptation. However, we find that as UPI increases in the population its relative fitness advantage diminishes in a frequency-dependent manner. The fitness benefits of UPI ‘leak’ into the biparentally reproducing part of the population through successive matings, limiting the spread of UPI. Critically, while this process favours some degree of UPI, it neither leads to the establishment of linked mating types nor the collapse of multiple mating types to two. Only when two mating types exist beforehand can associated UPI mutants spread to fixation under the pressure of high mitochondrial mutation rate, large mitochondrial population size and selfish mutants. Variation in these parameters could account for the range of UPI actually observed in nature, from strict UPI in someChlamydomonasspecies to BPI in yeast. We conclude that UPI of mitochondria alone is unlikely to have driven the evolution of two mating types in unicellular eukaryotes.
Databáze: OpenAIRE
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