Impairment by cyclosporin A of reperfusion-induced arrhythmias
| Autor: | Julieta Pichardo, Gloria Contreras, Rosa M. López, Diana Arteaga, Edmundo Chávez, Alberto Aranda, Elizabeth García, Alberto M Odor |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Heart disease medicine.medical_treatment Ischemia Blood Pressure Myocardial Reperfusion Injury Mitochondria Heart General Biochemistry Genetics and Molecular Biology Electrocardiography chemistry.chemical_compound Heart Rate Cyclosporin a Internal medicine Lactate dehydrogenase medicine Animals General Pharmacology Toxicology and Pharmaceutics Creatine Kinase Chemotherapy L-Lactate Dehydrogenase biology business.industry Myocardium Arrhythmias Cardiac Heart Rats Inbred Strains General Medicine medicine.disease Myocardial Contraction Rats Endocrinology Blood pressure chemistry Coronary occlusion Cyclosporine biology.protein Female Creatine kinase business |
| Zdroj: | Life Sciences. 51:1127-1134 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(92)90514-p |
| Popis: | This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca 2+ -induced damage of mitochondrial functions. |
| Databáze: | OpenAIRE |
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