Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish
| Autor: | Camille Akemann, Danielle N. Meyer, Chia-Chen Wu, Tracie R. Baker, Bridget B. Baker, Jeremiah N. Shields, Jessica Phillips, David K. Pitts |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Embryo Nonmammalian endocrine system diseases Health Toxicology and Mutagenesis Danio Physiology Embryonic Development Toxicology Bone and Bones Article Transcriptome Human fertilization Gene expression Medicine Animals Zebrafish Pharmacology Edema Cardiac biology Behavior Animal business.industry nutritional and metabolic diseases General Medicine Environmental exposure biology.organism_classification Phenotype Metformin Teratogens Female business Locomotion Water Pollutants Chemical medicine.drug |
| Zdroj: | Environ Toxicol Pharmacol |
| ISSN: | 1872-7077 |
| Popis: | Metformin is found in the majority of lakes and streams in the United States, leading to widespread environmental exposure. Results of the present study indicate that extended duration metformin exposure at critical developmental periods leads to decreased survival rates in zebrafish (danio rerio), an NIH approved human model. Significant abnormalities are seen with extended duration metformin exposure from 4 h post fertilization up to 5 days post fertilization, although short term metformin exposure for 24 h at 4–5 days post fertilization did not lead to any significant abnormalities. Both extended and short term duration did however have an impact on locomotor activity of zebrafish, and several genes involved in neurological and cardiovascular development were differentially expressed after exposure to metformin. The changes seen in behavior, gene expression and morphological abnormalities caused by metformin exposure should be examined further in future studies in order to assess their potential human health implications as metformin prescriptions continue to increase worldwide. |
| Databáze: | OpenAIRE |
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