18F-FDG-PET/MR increases diagnostic confidence in detection of bone metastases compared with 18F-FDG-PET/CT
| Autor: | Andrei Samarin, Patrick Veit-Haibach, Marcelo Queiroz, Paul Stolzmann, Gustav K. von Schulthess, Irene A. Burger, Martin Hüllner |
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| Přispěvatelé: | University of Zurich, Samarin, Andrei |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Whole body imaging 610 Medicine & health Bone Neoplasms Multimodal Imaging Sensitivity and Specificity 18f fdg pet Lesion 10043 Clinic for Neuroradiology Fluorodeoxyglucose F18 Image Processing Computer-Assisted medicine 2741 Radiology Nuclear Medicine and Imaging Humans Whole Body Imaging Radiology Nuclear Medicine and imaging Prospective cohort study neoplasms Aged PET-CT medicine.diagnostic_test 10042 Clinic for Diagnostic and Interventional Radiology business.industry Magnetic resonance imaging 10181 Clinic for Nuclear Medicine General Medicine Middle Aged Magnetic Resonance Imaging carbohydrates (lipids) Positron emission tomography Positron-Emission Tomography Female Fdg pet ct Radiology medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Nuclear Medicine Communications. 36:1165-1173 |
| ISSN: | 0143-3636 |
| Popis: | The aim of this study was to compare detection, lesion conspicuity and reader confidence of F-fluorodeoxyglucose (F-FDG)-PET/MR and F-FDG-PET/computed tomography (CT) in patients with F-FDG avid bone metastases.In this prospective study, a total of 30 PET/CT and PET/MRI data sets were performed in 24 patients. Each examination was evaluated for the presence of PET-positive bone lesions consistent with metastatic involvement. Conspicuity of PET-positive bone lesions was evaluated on the corresponding PET/CT and PET/MR images and compared using the Wilcoxon signed-ranks test. Reader confidence was determined to evaluate whether PET/CT or PET/MR was more useful for the assessment of the bone metastases and was compared using Student's t-test.Overall, in both examinations, PET/CT and PET/MRI detected 86 F-FDG-positive bone lesions. On all 30 PET/MRI examinations, at least one morphological correlate for F-FDG-positive bone lesions was found on the MR component (82 out of 86 lesions). PET/CT imaging allowed identification of corresponding structural changes on the CT component in 23 out of 30 studies (65 out of 86 lesions). In lesion-by-lesion analysis, the mean lesion conspicuity was significantly better on T1 fat MR imaging compared with CT imaging (P=0.005). In seven out of 30 studies, a significant increase in reader confidence of PET/MRI compared with PET/CT was found.PET/MRI offers higher reader confidence and improved conspicuity in bone metastases compared with PET/CT. However, the overall detection rate was not different. The highest possible clinical impact of PET/MRI appears to be in patients with limited, early bone metastatic disease. |
| Databáze: | OpenAIRE |
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