Angiotensin-Converting Enzyme Gene Polymorphism in Essential Hypertensive Patients in Japanese Population
| Autor: | Wataru Nishida, Shimin Li, Katsuhiko Kohara, Masayuki Takezaki, Takafumi Okura, Kunio Hiwada, Motofumi Maguchi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Molecular Sequence Data Peptidyl-Dipeptidase A 030204 cardiovascular system & hematology Essential hypertension Polymerase Chain Reaction law.invention 03 medical and health sciences 0302 clinical medicine Japan law Internal medicine Renin–angiotensin system medicine Humans 030212 general & internal medicine Family history Gene Polymerase chain reaction Polymorphism Genetic Base Sequence biology business.industry Intron Angiotensin-converting enzyme Middle Aged medicine.disease eye diseases Endocrinology Hypertension biology.protein Female Gene polymorphism Cardiology and Cardiovascular Medicine business |
| Zdroj: | Angiology. 47:643-648 |
| ISSN: | 1940-1574 0003-3197 |
| Popis: | Association between angiotensin-converting enzyme (ACE) gene polymorphism and essential hypertension in a Japanese population with the same socioeconomic back ground was investigated. Insertion-deletion (I/D) polymorphism of the ACE gene located on intron 16 was detected by polymerase chain reaction. Association between ACE gene polymorphism and family history of essential hypertension as well as the development of vascular damage in eye fundi were also investigated. Variation at ACE loci did not contribute to essential hypertension and the vascular damages in eye fundi. These results suggested that the ACE gene was not directly responsible for essential hypertension in this particular Japanese population with the same socioeconomic background. |
| Databáze: | OpenAIRE |
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