Deregulation of Soluble Adhesion Molecules in Resistant Hypertension and Its Role in Cardiovascular Remodeling
| Autor: | N. Correa, Rodrigo Modolo, Alessandra Mileni Versuti Ritter, Heitor Moreno, Andréa Rodrigues Sabbatini, V. Brunelli, Ana Paula de Faria |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Cardiomegaly Vascular Remodeling 030204 cardiovascular system & hematology Cardiovascular System Cohort Studies 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Internal medicine medicine Humans Platelet 030212 general & internal medicine Cell adhesion Pulse wave velocity Cell adhesion molecule business.industry General Medicine Adhesion medicine.disease P-Selectin Endocrinology Blood pressure Solubility Hypertension Arterial stiffness E-Selectin Cardiology and Cardiovascular Medicine business Cell Adhesion Molecules Biomarkers Selectin |
| Zdroj: | Circulation Journal. 80:1196-1201 |
| ISSN: | 1347-4820 1346-9843 1196-1201 |
| DOI: | 10.1253/circj.cj-16-0058 |
| Popis: | BACKGROUND Resistant hypertension (RHTN) and target organ damage are linked to increased inflammatory biomarkers, which may regulate adhesion molecules, such as intracellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1); and the platelet (P-selectin) and endothelial (E-selectin) selectins. We investigated a previously unknown relationship between soluble P-selectin (sP-selectin), E-selectin (sE-selectin), ICAM-1 (sICAM-1) and VCAM-1 (sVCAM-1) with RHTN and target organ damage. METHODS AND RESULTS We included 110 subjects diagnosed for true RHTN and 112 mild-moderate hypertensive (HTN) patients. Blood pressure parameters, pulse wave velocity and left ventricular mass index (LVMI) were measured. Adhesion molecules were measured on ELISA. Both sP-selectin and sE-selectin were increased; in contrast, sICAM-1 was reduced in RHTN compared with HTN patients, while similar sVCAM-1 was noted in the groups. sP-selectin and sVCAM-1 were elevated in the presence of arterial stiffness (sP-selectin: 104±47 vs. 89±45 ng/ml, P |
| Databáze: | OpenAIRE |
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