The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
| Autor: | Derksen, Jeroen W. G., Vink, Geraldine R., Elferink, Marloes A. G., Roodhart, Jeanine M. L., Verkooijen, Helena M., van Grevenstein, Wilhelmina M. U., Siersema, Peter D., May, Anne M., Koopman, Miriam, Beets, Geerard L., Belt, Eric J. Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L. O., van Cruijsen, Hester, Dekker, Jan Willem T., van Dodewaard-de Jong, Joyce M., Erdkamp, Frans L. G., de Groot, Jan Willem B., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H. J. T., Hoekstra, Ronald, Ijzermans, Jan N. M., Jansen, Jan, Kloppenberg, Frank W. H., van Lent, Anja U. G., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J. M., Nieboer, Peter, Peeters, Koen C. M. J., Peters, Natascha A. J. B., Polée, Marco B., Pruijt, Johannes F. M., Punt, Cornelis J. A., van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H. W., van der Velden, Arjan Schouten, Schrauwen, Ruud W. M., Sie, Mark P. S., Simkens, Lieke, Sommeijer, Dirkje W., Sonneveld, Dirk J. A., Spierings, Leontine E. A., Stockmann, Hein B. A. C., Talsma, Koen, Terheggen, Frederiek, ten Tije, Albert J., Tjin-A-Ton, Manuel L. R., Valkenburg-van Iersel, Liselot B. J., Veenstra, Renzo P., van der Velden, Ankie M. T., Vermaas, Maarten, Vles, Wouter J., Vogelaar, Jeroen F. J., van Voorthuizen, Theo, de Vos, Aad I., Wegdam, Johannes A., de Wilt, Johannes H. W., Zimmerman, David D. E. |
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| Přispěvatelé: | Surgery, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Epidemiologie, CCA - Cancer Treatment and quality of life, Radiology and nuclear medicine, Internal medicine, VU University medical center |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer Epidemiology Science Population MODELS MEDLINE Logistic regression Representativeness heuristic Article 03 medical and health sciences Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine Cancer epidemiology Medical research All institutes and research themes of the Radboud University Medical Center SDG 3 - Good Health and Well-being Multidisciplinary approach COLON medicine Humans 030212 general & internal medicine Prospective Studies Registries education Aged Netherlands Aged 80 and over education.field_of_study Multidisciplinary business.industry Middle Aged medicine.disease Cancer registry TRIALS Outcomes research 030220 oncology & carcinogenesis Family medicine Cohort Medicine Female business Colorectal Neoplasms |
| Zdroj: | Derksen, J W G, Vink, G R, Elferink, M A G, Roodhart, J M L, Verkooijen, H M, van Grevenstein, W M U, Siersema, P D, May, A M, Koopman, M, Beets, G L, Belt, E J T, Berbée, M, Beverdam, F H, Blankenburgh, R, Coene, P P L O, van Cruijsen, H, Dekker, J W T, van Dodewaard-de Jong, J M, Erdkamp, F L G, de Groot, J W B, Haringhuizen, A W, Helgason, H H, Hendriks, M P, de Hingh, I H J T, Hoekstra, R, Ijzermans, J N M, Jansen, J, Kloppenberg, F W H, van Lent, A U G, Los, M, Meijerink, M R, Mekenkamp, L J M, Nieboer, P, Peeters, K C M J, Peters, N A J B, Polée, M B, Pruijt, J F M, Punt, C J A, van Ufford-Mannesse, P Q, Rietbroek, R C, Schiphorst, A H W, van der Velden, A S, Schrauwen, R W M, Sie, M P S, Simkens, L, Sommeijer, D W, Sonneveld, D J A, Spierings, L E A, Stockmann, H B A C, Talsma, K, Terheggen, F, ten Tije, A J, Tjin-A-Ton, M L R, Valkenburg-van Iersel, L B J, Veenstra, R P, van der Velden, A M T, Vermaas, M, Vles, W J, Vogelaar, J F J, van Voorthuizen, T, de Vos, A I, Wegdam, J A, de Wilt, J H W, The PLCRC Study Group & Zimmerman, D D E 2021, ' The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care ', Scientific Reports, vol. 11, no. 1, 3923 . https://doi.org/10.1038/s41598-020-79890-y Scientific Reports, 11(1):3923. Nature Publishing Group Scientific Reports, 11, 1 Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports, 11 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-79890-y |
| Popis: | Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system. |
| Databáze: | OpenAIRE |
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