Variant Chromatin Structure of the oriP Region of Epstein-Barr Virus and Regulation of EBER1 Expression by Upstream Sequences and oriP
| Autor: | Paul J. Farrell, Peter J. Jenkins, Martine Hollyoake, Albert Stühler, Barbara Wensing, Claudio Elgueta Karstegl |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
DNA Replication
Gene Expression Regulation Viral Herpesvirus 4 Human Small RNA Transcription Genetic viruses Immunology medicine.disease_cause Microbiology Genome hemic and lymphatic diseases Virology medicine Promoter Regions Genetic Gene biology DNA replication virus diseases Nuclear matrix Epstein–Barr virus Molecular biology Chromatin Virus-Cell Interactions Insect Science DNA Viral biology.protein RNA Viral Micrococcal nuclease |
| Zdroj: | Journal of Virology. 75:6235-6241 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.75.13.6235-6241.2001 |
| Popis: | Most of the Epstein-Barr virus genome in latently infected cells is in a standard nucleosomal structure, but the region encompassing oriP and the Epstein-Barr virus-encoded small RNA (EBER) genes shows a distinctive pattern when digested with micrococcal nuclease. This pattern corresponds to a previously mapped nuclear matrix attachment region. Although the EBER genes are adjacent to oriP , there is only a two- to fourfold effect of oriP on EBER expression. However, sequences containing a consensus ATF site upstream of EBER1 are important for EBER1 expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|