Observations on the kidneys and urine of the wild Norway rat, Rattus norvegicus
| Autor: | R. N. Weaver, N. D. Connor, J. E. Gray |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Pathology Brown rat 040301 veterinary sciences Nephrosis Kidney Glomerulus Urine Biology Kidney Basement Membrane 0403 veterinary science Rodent Diseases 03 medical and health sciences Internal medicine medicine Animals Nematode Infections Pathological Inclusion Bodies Proteinuria General Veterinary Age Factors Capsule 04 agricultural and veterinary sciences Staphylococcal Infections biology.organism_classification medicine.disease Abscess Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Nematode Female Kidney Diseases medicine.symptom Atrophy Renal pelvis |
| Zdroj: | Veterinary pathology. 11(2) |
| ISSN: | 0300-9858 |
| Popis: | The kidneys of 39 wild Norway rats (Ranus norvegicus); 9 months or older, were examined for evidence of chronic progressive nephrosis, which commonly affects year-old albino rats. An infectious process resembling pyelonephritis was found in two rats. Protein absorption droplets, intranuclear inclusion bodies resembling those of lead intoxication, and large 'aberrant' nuclei were seen in the epithelial cells of the proximal convolutions. The nematode, Trichosomoides crassicauda, was found in the renal pelvis of approximately one fourth of the rats. Basement membranes of the glomerular tufts, Bowman's capsule and proximal tubule were examined in four rats by electron microscopy. The mean thickness of basement membranes of peripheral glomerular loops was 0.28 ± 0.09 11m, which is comparable to that of young healthy Sprague-Dawley rats. The protein content in 65 determinations of 24-hour serial collections of urine ranged from less than I to 3.9 mg/ml. No tendency was observed toward increased protein excretion or pro gressive deterioration of the kidneys, such as occurs in older Sprague-Dawley rats. This study was undertaken to learn whether a morphological or physio logical basis for chronic progressive nephrosis of the albino rat could be traced from its wild progenitor, the Norway or brown rat. It has previously been shown that in male Sprague-Dawley (Upjohn) rats over 1 year old the degree of proteinuria reflects rather well the extent of kidney degeneration (4). This association was found to exist in rats whether they excrete small (less than I mg/rnl) or large (over 20 mg/rnl) amounts of protein in the urine. These findings suggested that a genetic basis may underlie the difference in acceleration of proteinuria and kidney degeneration in the albino rat. Such a possibility has not been recognized to date, however, in studies of the effects of domestication, selection (9), and mutations (3) in the Norway rat. HABERMANN et al. (5) reported the pathological findings of 100 wild Norway rats that had been the survivors of a colony maintained under sirnu |
| Databáze: | OpenAIRE |
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