Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition
| Autor: | Patrizia Picerno, Anna Lisa Piccinelli, Seyed Mohammad Nabavi, Luca Rastrelli, Imma Pagano, Rita Celano, Osmany Cuesta Rubio, Adesegun Sunday, Francesca Sansone, Herbert Alexander Coker, Tiziana Esposito, Chinwendum Stephenie Alaribe |
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| Rok vydání: | 2019 |
| Předmět: |
Antioxidant
medicine.medical_treatment α-amylase and α-glucosidase enzymes Nigeria Plant Science 01 natural sciences Biochemistry Antioxidants Propolis Analytical Chemistry chemistry.chemical_compound Ingredient Nutraceutical free-radical scavenging activity medicine Glycoside Hydrolase Inhibitors Food science Amylase polyphenols chemistry.chemical_classification biology Helicobacter pylori 010405 organic chemistry Organic Chemistry Nigerian propolis alpha-Glucosidases 0104 chemical sciences 010404 medicinal & biomolecular chemistry Enzyme chemistry Polyphenol biology.protein alpha-Amylases Flavanone |
| DOI: | 10.6084/m9.figshare.10271723.v1 |
| Popis: | Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against α-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products. |
| Databáze: | OpenAIRE |
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