Interleukin‐25 recognition by its unique receptor IL‐17Rb via two discrete linear and cyclic epitopes

Autor:	Tao, Wu, Huaijun, Ma, Ping, He, Cheng, Zhang, Qingchen, Wu
Rok vydání:	2021
Předmět:	Pharmacology Receptors Interleukin-17 Interleukin-17 Drug Discovery Organic Chemistry Humans Thermodynamics Molecular Medicine Amino Acid Sequence Molecular Dynamics Simulation Peptides Biochemistry Protein Binding
Zdroj:	Chemical Biology & Drug Design. 99:382-390
ISSN:	1747-0285 1747-0277
DOI:	10.1111/cbdd.13993
Popis:	Interleukin-17 (IL-17) is a family of pro-inflammatory cytokines and has been involved in the pathogenesis of chronic inflammatory and autoimmune diseases. The IL-17E, also known as IL-25, is a distinct member of this family that binds to its unique receptor IL-17Rb to induce the activation of nuclear factor kappa-light-chain enhancer of activated B cells. Here, we systematically examined the intermolecular recognition and association of IL-25 with IL-17Rb and demonstrated that the IL-25 primarily adopts two discrete linear and cyclic epitopes to interact with IL-17Rb. The two epitopes are separately located in the monomers 1 and 2 of IL-25 homodimer and cover sequences
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f11d1065d195a6b0a7a19f9ff9c805 https://doi.org/10.1111/cbdd.13993 Zobrazit plný text záznamu Plný text