Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients
| Autor: | Kwang-Won Kim, Se Won Kim, Hyung-Doo Park, Jae Hyeon Kim, Moon-Kyu Lee, Sunghwan Suh, Kyu Yeon Hur, Hye Soo Chung, Ji Cheol Bae, Alice Hyun-Kyung Tan |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology Coronary artery disease chemistry.chemical_compound Diabetes mellitus Internal medicine medicine Myocardial infarction lcsh:RC648-665 business.industry Hypertriglyceridemia Type 2 Diabetes Mellitus Coronary heart diseases medicine.disease Small dense low density lipoprotein Stenosis Endocrinology chemistry Low-density lipoprotein LDL particle size Cardiology Original Article business Vascular Stenosis |
| Zdroj: | Diabetes & Metabolism Journal Diabetes & Metabolism Journal, Vol 35, Iss 5, Pp 536-542 (2011) |
| ISSN: | 2233-6087 |
| Popis: | Background: Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease. Methods: The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (≥50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications. Results: Diabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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