Modulating Effect of Enicostemma littorale on the Expression Pattern of Apoptotic, Cell Proliferative, Inflammatory and Angiogenic Markers During 7, 12-Dimethylbenz (a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis
| Autor: | Sekar Karthikeyan, Shanmugam Manoharan, Murugaraj Manoj Prabhakar, Duraisamy Rajasekaran, Asokan Manimaran |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Angiogenesis Health Toxicology and Mutagenesis DMBA Toxicology chemistry.chemical_compound stomatognathic system medicine Enicostemma littorale biology Cell growth 7 12-Dimethylbenz[a]anthracene apoptosis Buccal administration oral cancer Proliferating cell nuclear antigen Vascular endothelial growth factor stomatognathic diseases cell proliferation chemistry Apoptosis inflammation Cancer research biology.protein Original Article |
| Zdroj: | Toxicology International |
| ISSN: | 0971-6580 |
| Popis: | Enicostemma littorale leaves are traditionally used for the treatment of several diseases, including inflammation and cancer. This study has taken effort to explore the antitumor initiating potential of E. littorale leaves (ElELet) by analyzing the expression pattern of apoptotic (p53, Bcl-2 and Bcl-2 associated X-protein), cell-proliferative (cyclin D1 and proliferating cell nuclear antigen), angiogenic (vascular endothelial growth factor), invasive (matrix metalloproteinase-2 and 9), and inflammatory (NF-κB and cyclooxygenase-2) markers during 7, 12-dimethylbenz (a) anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral tumors were induced in the buccal pouches of hamsters using the potent site and organ specific carcinogen, DMBA. DMBA application 3 times a week for 14 weeks resulted in tumor formation in the buccal pouches. Hundred percent tumor formations with dysregulation in the expression pattern of apoptotic, cell proliferative, inflammatory, angiogenic, and invasive markers were observed in the buccal pouches of hamsters treated with DMBA alone. ElELet at a dose of 250 mg/kg body weight orally to DMBA treated hamsters significantly prevented the tumor formation as well as corrected the abnormalities in the expression pattern of above mentioned molecular markers. ElELet thus modulated the expression pattern of all the above mentioned molecular markers in favor of the suppression of cell proliferation occurring in DMBA induced hamster buccal pouch carcinogenesis. |
| Databáze: | OpenAIRE |
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