Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus
| Autor: | G.G. Figueiredo, O.A. Coronel, A.C. Trabuco, D.E. Bazán, R.R. Russo, N.L. Alvarenga, V.H. Aquino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Medicine (General) QH301-705.5 Physiology viruses Immunology Biophysics Ocean Engineering Dengue virus Biology Solanum Virus Replication medicine.disease_cause Antiviral Agents Biochemistry Virus Dengue fever 03 medical and health sciences Solanum sisymbriifolium R5-920 0302 clinical medicine medicine Biology (General) General Pharmacology Toxicology and Pharmaceutics Antiviral REPLICAÇÃO VIRAL General Neuroscience Yellow fever Cell Biology General Medicine Saponins medicine.disease biology.organism_classification Virology Flavivirus 030104 developmental biology 030220 oncology & carcinogenesis Vero cell Virucidal Yellow fever virus Research Article |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 54, Issue: 7, Article number: e10240, Published: 17 MAY 2021 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Medical and Biological Research, Vol 54, Iss 7 (2021) Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research v.54 n.7 2021 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | Dengue is the most important arthropod-borne viral disease worldwide. Infection with any of the four dengue virus (DENV) serotypes can be asymptomatic or lead to disease with clinical symptoms ranging from undifferentiated and self-limiting fever to severe dengue disease, which can be fatal in some cases. Currently, no specific antiviral compound is available for treating DENV. The aim of this study was to identify compounds in plants from Paraguayan folk medicine with inhibitory effects against DENV. We found high virucidal activity (50% maximal effective concentration (EC50) value of 24.97 µg/mL) against DENV-2 in the ethanolic extract of the roots of Solanum sisymbriifolium Lam. (Solanaceae) without an evident cytotoxic effect on Vero E6 cells. Three saponins isolated from the root extract showed virucidal effects (EC50 values ranging from 24.9 to 35.1 µg/mL) against DENV-2. Additionally, the saponins showed inhibitory activity against yellow fever virus (EC50 values ranging from 126 to 302.6 µg/mL), the prototype virus of the Flavivirus genus, suggesting that they may also be effective against other members of this genus. Consequently, these saponins may be lead compounds for the development of antiviral agents. |
| Databáze: | OpenAIRE |
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