Regional Distribution of Fluorine-18-Flubrobenguane and Carbon-11-Hydroxyephedrine for Cardiac PET Imaging of Sympathetic Innervation
| Autor: | RN Sarah Quigley, Braeden Mair, Robert A. deKemp, Benjamin H. Rotstein, RN Olga Walter, Lisa Mielniczuk, Jason G.E. Zelt, RN Linda Garrard, Deron Britt, Rob S. Beanlands, Simon Robinson |
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| Rok vydání: | 2021 |
| Předmět: |
Fluorine Radioisotopes
medicine.medical_specialty Sympathetic nervous system 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging Sudden cardiac death 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Distribution (pharmacology) Radiology Nuclear Medicine and imaging Carbon Radioisotopes Denervation Ischemic cardiomyopathy Ejection fraction medicine.diagnostic_test business.industry medicine.disease medicine.anatomical_structure Positron emission tomography Cardiac PET Positron-Emission Tomography Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC: Cardiovascular Imaging. 14:1425-1436 |
| ISSN: | 1936-878X |
| DOI: | 10.1016/j.jcmg.2020.09.026 |
| Popis: | Objectives The aim of this study was to investigate the regional distribution of novel 18F-labeled positron emission tomographic (PET) tracer flubrobenguane (FBBG) (whose longer half-life could enable more widespread use) to assess myocardial presynaptic sympathetic nerve function in humans in comparison to [11C]meta-hydroxyephedrine (HED). Background The sympathetic nervous system (SNS) is vitally linked to cardiovascular regulation and disease. SNS imaging has shown prognostic value. HED is the most commonly used PET tracer for evaluation of sympathetic function in humans, but widespread clinical use is limited because of the short half-life of 11C. Methods A total of 25 participants (n = 6 healthy; n = 14 ischemic cardiomyopathy, left ventricular [LV] ejection fraction [EF] = 34 ± 5%; and n = 5 nonischemic cardiomyopathy, EF = 33 ± 3%) underwent 2 separate PET imaging visits 8.7 ± 7.6 days apart. On 1 visit, participants underwent dynamic HED PET imaging. On a different visit, participants underwent dynamic FBBG PET imaging. The order of testing was random. HED and FBBG global innervation (retention index [RI] and distribution volume [DV]) and regional denervation (% nonuniformity) were quantified to assess regional presynaptic sympathetic innervations. Results FBBG RI (r2 = 0.72; ICC = 0.79; p Conclusions FBBG and HED yield equivalent global and regional distributions in both patients with and without ischemic cardiomyopathy. 18F-labeled PET tracers, such as FBBG, are critical for widespread distribution necessary for multicenter clinical trials and to maximize patient impact. |
| Databáze: | OpenAIRE |
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