Genetic Variation in One-Carbon Metabolism and Changes in Metabolic Parameters in First-Episode Schizophrenia Patients
| Autor: | Ryszard Ślęzak, Elżbieta Szmida, Patryk Piotrowski, Natalia Sloka, Andrzej Kiejna, Dorota Frydecka, Błażej Misiak, Łukasz Łaczmański |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Waist Genotype MTHFD1 metabolic syndrome polymorphism Body Mass Index Minor Histocompatibility Antigens 03 medical and health sciences Young Adult 0302 clinical medicine Polymorphism (computer science) Internal medicine medicine Humans Pharmacology (medical) Regular Research Article Methylenetetrahydrofolate Reductase (NADPH2) Pharmacology Genetics Methylenetetrahydrofolate Dehydrogenase (NADP) antipsychotic-induced weight gain Polymorphism Genetic biology medicine.disease MTRR methylenetetrahydrofolate reductase digestive system diseases Ferredoxin-NADP Reductase Psychiatry and Mental health 030104 developmental biology Endocrinology Betaine-Homocysteine S-Methyltransferase Methylenetetrahydrofolate reductase MTHFR biology.protein Schizophrenia Female Metabolic syndrome Waist Circumference Body mass index 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | International Journal of Neuropsychopharmacology |
| ISSN: | 1469-5111 1461-1457 |
| Popis: | Background: In this study, we aimed to investigate the effects of polymorphisms in genes encoding 1-carbon metabolism enzymes on differential development of metabolic parameters during 12 weeks of treatment with second-generation antipsychotics in first-episode schizophrenia patients. Methods: The following polymorphisms in 1-carbon metabolism genes were genotyped: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G), and BHMT (G742A). A broad panel of metabolic parameters including body mass index, waist circumference, total cholesterol low and high density lipoproteins, triglycerides, homocysteine, folate, and vitamin B12 was determined. Results: There was a significant effect of the interaction between the MTHFR C677T polymorphism and time on body mass index and waist circumference in the allelic and genotype analyses. Indeed, patients with the MTHFR 677CC genotype had higher increase in body mass index and waist circumference compared with other corresponding genotypes or the MTHFR 677T allele carriers (CT and TT genotypes). In addition, patients with the MTHFR 677TT genotype had higher waist circumference in all time points. Similarly, patients with the MTHFR 677TT genotype had higher body mass index in all time points, but this effect was not significant after correction for multiple testing. Conclusions: Our results indicate that the MTHFR C677T polymorphism may predict antipsychotic-induced weight gain. Effects of the MTHFR C677T polymorphism might be different in initial exposure to antipsychotics compared with long-term perspective. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|