High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo
| Autor: | Carly Pellow, Eric C. Abenojar, Gang Zheng, David E. Goertz, Agata A. Exner, Christine E. M. Demore, Emmanuel Cherin |
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| Rok vydání: | 2021 |
| Předmět: |
Diagnostic Imaging
Materials science Acoustics and Ultrasonics media_common.quotation_subject Contrast Media 01 natural sciences Article Imaging phantom 030218 nuclear medicine & medical imaging Amplitude modulation 03 medical and health sciences 0302 clinical medicine In vivo 0103 physical sciences Contrast (vision) Electrical and Electronic Engineering 010301 acoustics Instrumentation Ultrasonography media_common Phantoms Imaging business.industry Scattering Ultrasound Nonlinear system business Sensitivity (electronics) Biomedical engineering |
| Zdroj: | IEEE Trans Ultrason Ferroelectr Freq Control |
| ISSN: | 1525-8955 0885-3010 |
| Popis: | There has been growing interest in nanobubbles for vascular and extravascular ultrasound contrast imaging and therapeutic applications. Studies to date have generally utilized low frequencies (109 mL(−1)), and uncalibrated B-mode or contrast-mode on commercial systems without reporting investigations on nanobubble signatures upon which the imaging protocols should be based. We recently demonstrated that low concentrations (106 mL(−1)) of porphyrin-lipid encapsulated nanobubbles scatter nonlinearly at low (2.5, 8 MHz) and high (12.5, 25, 30 MHz) frequencies in a pressure threshold-dependent manner that is advantageous for amplitude modulation imaging. Here we implement pressure-calibrated amplitude modulation at high frequency on a commercial preclinical array system to enhance sensitivity to nonlinear scattering of three phospholipid-based nanobubble formulations. With this approach, improvements in contrast to tissue ratio relative to B-mode between 12.4 and 22.8 dB are demonstrated in a tissue-mimicking phantom, and between 6.7 and 14.8 dB in vivo. |
| Databáze: | OpenAIRE |
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