Electroconvulsive therapy increases brain volume in major depression: a systematic review and meta-analysis
| Autor: | K. Gbyl, Poul Videbech |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Hippocampus Brain damage behavioral disciplines and activities White matter 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Internal medicine mental disorders Humans Medicine Prospective Studies Electroconvulsive Therapy Depressive Disorder Major Neuronal Plasticity medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Organ Size Magnetic Resonance Imaging White Matter 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Meta-analysis Brain size Cardiology Female medicine.symptom business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Acta Psychiatrica Scandinavica. 138:180-195 |
| ISSN: | 0001-690X |
| DOI: | 10.1111/acps.12884 |
| Popis: | Objective The main purpose of this review was to synthesise evidence on ECT's effects on brain's structure. Method A systematic literature review of longitudinal studies of depressed patients treated with ECT using magnetic resonance imaging (MRI) and meta-analysis of ECT's effect on hippocampal volume. Results Thirty-two studies with 467 patients and 285 controls were included. The MRI studies did not find any evidence of ECT-related brain damage. All but one of the newer MRI volumetric studies found ECT-induced volume increases in certain brain areas, most consistently in hippocampus. Meta-analysis of effect of ECT on hippocampal volume yielded pooled effect size: g = 0.39 (95% CI = 0.18-0.61) for the right hippocampus and g = 0.31 (95% CI = 0.09-0.53) for the left. The DTI studies point to an ECT-induced increase in the integrity of white matter pathways in the frontal and temporal lobes. The results of correlations between volume increases and treatment efficacy were inconsistent. Conclusion The MRI studies do not support the hypothesis that ECT causes brain damage; on the contrary, the treatment induces volume increases in fronto-limbic areas. Further studies should explore the relationship between these increases and treatment effect and cognitive side effects. |
| Databáze: | OpenAIRE |
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