Body Pigmentation as a Risk Factor for the Formation of Intracranial Aneurysms
| Autor: | Viktoria R. Rübenbauer, Elke Kronawetter, Klaus Leber, Ilona Papousek, Peter Konstantiniuk, Günter Schulter |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Article Subject lcsh:Medicine Skin Pigmentation Inflammation Biology General Biochemistry Genetics and Molecular Biology Brain arteries Pathogenesis Risk Factors Eye color medicine Humans Risk factor Hair Color Aged Eye Color General Immunology and Microbiology lcsh:R Developmental pigmentation Case-control study Intracranial Aneurysm General Medicine Middle Aged Eye pigmentation Case-Control Studies Female sense organs medicine.symptom Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2014/301631 |
| Popis: | Recent studies demonstrated pigmented cells both in the murine heart, in pulmonary veins, and in brain arteries. Moreover, a role for melanocytes in the downregulation of inflammatory processes was suggested. As there is increasing evidence that inflammation is contributing significantly to the pathogenesis of intracranial aneurysms, melanocyte-like cells may be relevant in preventing age-related impairment of vessels. As pigmentation of the heart reflects that of coat color, aspects of body pigmentation might be associated with the incidence of intracranial aneurysms. We performed a case-control study to evaluate associations between the pigmentation of hair and eyes and the formation of aneurysms. In addition to hair and eye color, constitutive and facultative skin pigmentation were assessed in a replication study as well as individual handedness which can be seen as a neurophysiological correlate of developmental pigmentation processes. Hair pigmentation was highly associated with intracranial aneurysms in both samples, whereas eye pigmentation was not. In the replication cohort, facultative but not constitutive skin pigmentation proved significant. The strongest association was observed for individual handedness. Results indicate a significant association of intracranial aneurysms with particular aspects of body pigmentation as well as handedness, and imply clinical usefulness for screening of aneurysms and possible interventions. |
| Databáze: | OpenAIRE |
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