Prediction of metaphase II oocytes according to different serum Anti-Müllerian hormone (AMH) levels in antagonist ICSI cycles
| Autor: | Souza, Marcelo Marinho de Souza, Joyce Barreto da Silva, Tatiana R Panaino, Patricia Areas, Ana Cristina Allemand Mancebo, Roberto de Azevedo Antunes, Paloma Lira, Maria A Tamm |
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| Rok vydání: | 2016 |
| Předmět: |
metaphase II oocytes
endocrine system 030219 obstetrics & reproductive medicine Anti-Müllerian hormone (AMH) IVF outcome biology Metaphase ii business.industry Antagonist Anti-Müllerian hormone Stimulation controlled ovarian stimulation Antral follicle Single Center Andrology 03 medical and health sciences 0302 clinical medicine Patient age biology.protein Medicine Original Article 030212 general & internal medicine business ovarian response Hormone |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| DOI: | 10.5935/1518-0557.20160043 |
| Popis: | Objective This paper aims to assess a qualitative aspect of ovarian response in terms of metaphase II oocytes according to different serum Anti-Müllerian hormone levels in antagonist ICSI cycles. A prediction index might contribute to the individualization of care. Methods This observational study looked into 287 antagonist ICSI cycles carried out with patients treated in a single center between January of 2012 and January of 2016. Serum AMH and subgroup analyses were performed based on five AMH ranges (≤ 0.3 ng/mL;> 0.3 and ≤ 0.7 ng/mL; > 0.7 and ≤ 1.0 ng/mL; > 1.0 and < 3.0 ng/mL; ≥ 3.0 ng/mL). The variables analyzed included patient age; serum FSH and antral follicle count at the start of the cycle; number of stimulation days and number follicles ≥ 15 mm on hCG day; number of oocytes retrieved and number of metaphase II oocytes. Results AMH is a better predictor of ovarian response to controlled ovarian stimulation than AFC or serum FSH, while age is an independent marker. AMH levels ≤0.70 (patients with poor prognosis) were observed in 140 patients (48.7%). Patients within this AMH level range accounted for 92% of the 24 failed cycles (cancelled cycles, no oocytes or immature oocytes retrieved). Conclusion AMH predicts the quality of ovarian response to stimulation, regardless of patient age. Women with AMH levels ≥1.0 and ≤3.0 ng/mL are probably normal responders with good prognosis. Clinical application relies on the examination of the data from each individual center and on the establishment of correlations between AMH levels and ovarian response in the form of metaphase II oocytes. |
| Databáze: | OpenAIRE |
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