Laterodorsal tegmentum and pedunculopontine tegmental nucleus circuits regulate renal functions: Neuroanatomical evidence in mice models
| Autor: | Waiping Zhou, Feng Gao, Cheng Liu, Rong-Chun Li, Qing-Qing Guo, Ling Zhou, Jueping Feng, Hong-Bing Xiang, Hui Yang, Da-Wei Ye |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Tegmentum Mesencephali viruses Biomedical Engineering Biology Kidney Serotonergic Biochemistry Biomaterials Mice Neural Pathways Pedunculopontine Tegmental Nucleus Genetics Tegmentum Animals Earth-Surface Processes Feedback Physiological Neurons Catecholaminergic Anatomy Laterodorsal tegmentum Mice Inbred C57BL nervous system Medicine public health Nerve Net |
| Zdroj: | Journal of Huazhong University of Science and Technology [Medical Sciences]. 32:216-220 |
| ISSN: | 1993-1352 1672-0733 |
| DOI: | 10.1007/s11596-012-0038-2 |
| Popis: | Neurons in the laterodorsal tegmentum (LDTg) and pedunculopontine tegmental nucleus (PPTg) play important roles in central autonomic circuits of the kidney. In this study, we used a combination of retrograde tracers pseudorabies virus (PRV)-614 and fluorescence immunohistochemistry to characterize the neuroanatomic substrate of PPTg and LDTg innervating the kidney in the mouse. PRV-614-infected neurons were retrogradely labeled in the rostral and middle parts of LDTg, and the middle and caudal parts of PPTg after tracer injection in the kidney. PRV-614/TPH double-labeled neurons were mainly localized in the rostral of LDTg, whereas PRV-614/TH neurons were scattered within the three parts of LDTg. PRV-614/TPH and PRV-614/TH neurons were located predominantly in the caudal of PPTg (cPPTg). These data provided direct neuroanatomical foundation for the identification of serotonergic and catecholaminergic projections from the mid-brain tegmentum to the kidney. |
| Databáze: | OpenAIRE |
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