Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency
| Autor: | Themis Maria Milan Brochado, Andréia Conceição Milan Brochado Antoniolli-Silva, Naudimar Di Pietro Simões, Laynna de Carvalho Schweich, Rodrigo Juliano Oliveira |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Inflammation Dermatology Haematoxylin Silver sulfadiazine Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sulfadiazine Internal medicine medicine Animals 030212 general & internal medicine Rats Wistar Saline Wound Healing biology business.industry Original Articles Carbon Dioxide Silver Sulfadiazine Fibronectins Rats Fibronectin Venous Insufficiency chemistry biology.protein Immunohistochemistry Surgery medicine.symptom business Wound healing medicine.drug |
| Zdroj: | Int Wound J |
| ISSN: | 1742-481X 1742-4801 |
| DOI: | 10.1111/iwj.13031 |
| Popis: | To examine the influence of carboxytherapy on wound healing under venous insufficiency, full-thickness excisional wounds were created on Wistar rats. We used three groups with 32 rats each: Group (I): daily cleaning with 0.9% saline solution; Group Sulfadiazine (II): 1% silver sulfadiazine; and Carboxytherapy (III): subcutaneous application of 0.3 mL of carbon dioxide. The predetermined periods of analysis were the 3rd, 7th, 14th, and 30th day. The slides were stained with haematoxylin and eosin and Picrosirius red and submitted for immunohistochemistry. Groups II and III presented a statistically significant decrease in relation to the presence of neutrophilic and lymphocytic infiltrates. The presence of collagen significant increased in groups II and III. However, group III presented better organisation. Only group I maintained the neovascularisation until the 30th day. The new epithelium statistically significantly increased in groups II and III. On immunohistochemistry, regarding fibronectin expression, only group III demonstrated a statistically significant increase since the beginning of the healing process. Thus, the use of carboxytherapy promotes the formation of a tissue better structured and that may be an important resource for the treatment of wounds under venous insufficiency, especially those of recurrent re-openings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text