Preliminary evaluation of a polyethyleneglycol-stabilized manganese-substituted hydroxylapatite as an intravascular contrast agent for MR angiography
| Autor: | Michael R. Hynes, Debiao Li, Kofi Adzamli, Dennis L. Nosco, Richard B. Dorshow, Max D. Adams |
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| Rok vydání: | 1997 |
| Předmět: |
Surface Properties
Contrast Media chemistry.chemical_element Polyethylene glycol Paramagnetic Contrast Agent Manganese In Vitro Techniques Body weight Polyethylene Glycols chemistry.chemical_compound Drug Stability PEG ratio Animals Radiology Nuclear Medicine and imaging Particle Size Mean diameter business.industry Chemistry Mr angiography Hydroxylapatite Durapatite Evaluation Studies as Topic Injections Intravenous Hydroxyapatites Rabbits Nuclear medicine business Magnetic Resonance Angiography Half-Life Nuclear chemistry |
| Zdroj: | Journal of Magnetic Resonance Imaging. 7:204-208 |
| ISSN: | 1522-2586 1053-1807 |
| DOI: | 10.1002/jmri.1880070131 |
| Popis: | A blood-persistent particulate paramagnetic contrast agent has been formulated via size stabilization of manganese-substituted hydroxylapatite by a polyethylene glycol (PEG) bearing a terminal diphosphonate. At high PEG surface densities (35-40 mol%), particles with mean diameter 8 +/- 2 nm were obtained. Relaxivities of autoclaved samples (at 20 MHz proton Lamor frequency) were R1 = 18.7 +/- .8 mM-1 sec-1 and R2 = 22.3 +/- .7 mM-1 sec-1. The formulation persisted in rabbit blood with a biphasic clearance profile. Half-lives (with amplitudes in parenthesis) were 4 +/- 1 minutes (55%), and 49 +/- 3 minutes (45%), respectively, for the two phases. A dose of 40 mumol Mn/kg body weight enhanced the signal from rabbit vasculature for more than 45 minutes on MR angiograms. Thus, PEG-modified MnHA particles may find use as T1 agents for MR angiography. |
| Databáze: | OpenAIRE |
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