Antiplatelet Drugs for Neurointerventions: Part 1 Clinical Pharmacology
| Autor: | Joshua A Hirsch, Ronil V. Chandra, Kenny Li, Hamed Asadi, Jeremy Russell, Hong Kuan Kok, Samuel Pearce, Christen D. Barras, Mark Brooks, Vincent Thijs, Ash Jhamb, Julian Maingard |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Platelets
medicine.medical_specialty medicine.medical_treatment 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine law medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Thrombus Intensive care medicine Clinical pharmacology business.industry Endovascular Procedures Stent Percutaneous coronary intervention Intracranial Aneurysm Thrombosis medicine.disease Clopidogrel Eptifibatide Neurology (clinical) Neurosurgery business Platelet Aggregation Inhibitors 030217 neurology & neurosurgery Forecasting medicine.drug |
| Zdroj: | Clinical Neuroradiology. 30:425-433 |
| ISSN: | 1869-1447 1869-1439 |
| Popis: | The development of endovascular treatment for intracranial aneurysms has established new techniques such as balloon and stent-assistance, flow diversion and endosaccular occlusion devices. Antiplatelet treatment is an important aspect to reduce risk of thrombus formation on microcatheters and implanted devices when utilizing these methods. It is particularly relevant for flow diverting stents to prevent early and late stent thrombosis. Consideration of platelet physiology and appropriate selection of antiplatelet medication is important as platelet dysfunction drives many of the pathological processes and complications of neurointerventional procedures. Part one of this review focuses on basic platelet physiology, pharmacology of common antiplatelet medications and future directions and therapies. Part two focuses on clinical applications and evidence-based therapeutic regimens. |
| Databáze: | OpenAIRE |
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