A Study of 219Rn Outgassing and 211Pb Contamination from 223Ra In dry, Liquid, and Murine Tissue Samples

Autor: Peter L. Choyke, Stephen Adler, Frank Lin, Tim Phelps, Jyoti Roy, Jurgen Seidel, Kwamena E. Baidoo, Elaine M. Jagoda
Rok vydání: 2019
Předmět:
Zdroj: Health Phys
ISSN: 1538-5159
0017-9078
DOI: 10.1097/hp.0000000000001132
Popis: INTRODUCTION: A study of (211)Pb contamination caused by the outgassing of (219)Rn from (223)Ra in dry, liquid, and murine tissues samples has been made to help design proper handling procedures for (223)Ra in preclinical biodistribution work. MATERIALS AND METHODS: (211)Pb activity levels were measured from (223)Ra in dry, liquid, and tissue samples using aspiration and autoradiography techniques. RESULTS: Using aspiration techniques on dry samples of (223)Ra, an average (219)Rn outgassing rate of 51% ± 21% was measured with one measurement reaching as high as 81%. 31% ± 4% (211)Pb contamination was measured within a 4.3 cm radius of a dry (223)Ra source placed inside a 10-cm-diameter petri dish where the lip of the petri dish contained the (219)Rn dissemination. Without the containment of the petri dish, (219)Rn can reach as far as 7.8 cm from the source with trace levels spreading further. Using aspiration techniques on liquid samples of (223)Ra, outgassing rates of (219)Rn were 0.9% ± 0.3%. The outgassing levels in harvested organs from a biodistribution were as high as 10.1% ± 0.4% for an intraperitoneally injected mouse and 0.204% ± 0.006% for an intravenously injected mouse. The outgassing of the intravenously injected mouse carcass was less than 0.1%. CONCLUSION: In dry form, the high levels of (219)Rn outgassing from a (223)Ra source necessitate the use of ventilated biohoods when handling or preparing dry (223)Ra from source vials. The very low levels of (219)Rn outgassing from (223)Ra liquid sources reduces exposure to (219)Rn by a factor of 50. (219)Rn exposure from murine organ tissue reaches levels of 10% when handling organs from an intraperitoneal injection and less than 0.2% for an intravenous injection.
Databáze: OpenAIRE
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