Utility of using electrocardiogram measures of heart rate variability as a measure of cardiovascular autonomic neuropathy in type 1 diabetes patients
| Autor: | Dcct, Elsayed Z. Soliman, Ionut Bebu, Neil H. White, John M. Lachin, Jye-Yu C. Backlund, Barbara H. Braffett, Rodica Pop-Busui, Gayle M. Lorenzi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Cardiovascular autonomic neuropathy Sensitivity and Specificity Diseases of the endocrine glands. Clinical endocrinology Standard deviation Electrocardiography Cohen's kappa Diabetic Neuropathies Heart Rate Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Heart rate variability Randomized Controlled Trials as Topic Type 1 diabetes business.industry fungi Area under the curve Reproducibility of Results food and beverages Articles General Medicine Gold standard (test) Middle Aged RC648-665 medicine.disease Cardiovascular reflex tests Confidence interval Diabetes Mellitus Type 1 Clinical Science and Care Autonomic Nervous System Diseases Cardiovascular Diseases Cardiology Female Original Article business Diabetic Angiopathies |
| Zdroj: | Journal of Diabetes Investigation Journal of Diabetes Investigation, Vol 13, Iss 1, Pp 125-133 (2022) |
| ISSN: | 2040-1124 2040-1116 |
| DOI: | 10.1111/jdi.13635 |
| Popis: | Aims/Introduction Cardiovascular autonomic neuropathy (CAN) is a predictor of cardiovascular disease and mortality. Cardiovascular reflex tests (CARTs) are the gold standard for the diagnosis of CAN, but might not be feasible in large research cohorts or in clinical care. We investigated whether measures of heart rate variability obtained from standard electrocardiogram (ECG) recordings provide a reliable measure of CAN. Materials and Methods Standardized CARTs (R‐R response to paced breathing, Valsalva, postural changes) and digitized 12‐lead resting ECGs were obtained concomitantly in Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications participants (n = 311). Standard deviation of normally conducted R‐R intervals (SDNN) and the root mean square of successive differences between normal‐to‐normal R‐R intervals (rMSSD) were measured from ECG. Sensitivity, specificity, probability of correct classification and Kappa statistics evaluated the agreement between ECG‐derived CAN and CARTs‐defined CAN. Results Participants with CARTs‐defined CAN had significantly lower SDNN and rMSSD compared with those without CAN (P Participants with cardiovascular reflex tests‐defined cardiovascular autonomic neuropathy (CAN) had significantly lower standard deviation of normally conducted R‐R intervals and root mean square of successive differences between normal‐to‐normal R‐R intervals compared to those without CAN (P |
| Databáze: | OpenAIRE |
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