Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans
Autor: | Anne Lee, John Neuhaus, Allison E. Aiello, Tu My To, Michelle C. Odden, Mary N. Haan |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Gerontology
Male Aging Activities of daily living Epidemiology Disease Cardiovascular Body Mass Index 0302 clinical medicine Risk Factors Surveys and Questionnaires Activities of Daily Living Mexican Americans Prevalence Minority aging 030212 general & internal medicine Longitudinal Studies Incidence (epidemiology) Incidence Rehabilitation Middle Aged Cardiovascular Diseases Disease Progression Female Type 2 Cohort study Research Article medicine.medical_specialty Clinical Sciences education 03 medical and health sciences Osteoarthritis medicine Diabetes Mellitus Humans Obesity Sex Distribution Aged business.industry Arthritis medicine.disease Comorbidity United States Functional performance Diabetes Mellitus Type 2 Musculoskeletal Geriatrics and Gerontology business Body mass index human activities 030217 neurology & neurosurgery Follow-Up Studies |
Zdroj: | Haan, MN; Lee, A; Odden, MC; Aiello, AE; To, TM; & Neuhaus, JM. (2016). Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 71(8), 1089-1095. doi: 10.1093/gerona/glw014. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1qs4q63g The journals of gerontology. Series A, Biological sciences and medical sciences, vol 71, iss 8 |
Popis: | BackgroundComorbidity (COM) is an important issue in aging. Cardiovascular disease (CVD) and osteoarthritis separately and together may modify the trajectories of functional decline. This analysis examines whether specific and unrelated COMs influence functional change differently and vary by gender.MethodsA cohort study of 1,789 (aged 60 years and older) Mexican Americans was followed annually for up to 10 years. We created four groups of COM (CVD alone, lower body osteoarthritis alone [OA], neither, or both). We employed mixed effects Poisson models with Instrumental Activities of Daily Living (IADL) as the outcome. We tested whether the association between COM and decline in functional status differed by gender.ResultsIADL impairments in those with CVD, OA, or both were significantly higher at baseline and increased more rapidly over time compared to those with neither condition. Compared to women with no COM, the number of IADL impairments in women with CVD alone were 1.36 times greater, with OA were 1.35 times greater, and both conditions were 1.26 times greater. Compared to men with no COM, IADL impairments in men with CVD alone were 1.15 times greater, OA alone were 1.12 times greater, and both were 1.26 times greater.ConclusionsOver time, the influence of COM on functional decline differs by specific combinations of COM and by gender. Aggregate COM scales obscure the biological and temporal heterogeneity in the effects of COM. Time-dependent-specific COMs better assess the development of impairment. Women experience a higher burden of functional impairment due to COM than men. |
Databáze: | OpenAIRE |
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