Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans

Autor: Anne Lee, John Neuhaus, Allison E. Aiello, Tu My To, Michelle C. Odden, Mary N. Haan
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Gerontology
Male
Aging
Activities of daily living
Epidemiology
Disease
Cardiovascular
Body Mass Index
0302 clinical medicine
Risk Factors
Surveys and Questionnaires
Activities of Daily Living
Mexican Americans
Prevalence
Minority aging
030212 general & internal medicine
Longitudinal Studies
Incidence (epidemiology)
Incidence
Rehabilitation
Middle Aged
Cardiovascular Diseases
Disease Progression
Female
Type 2
Cohort study
Research Article
medicine.medical_specialty
Clinical Sciences
education
03 medical and health sciences
Osteoarthritis
medicine
Diabetes Mellitus
Humans
Obesity
Sex Distribution
Aged
business.industry
Arthritis
medicine.disease
Comorbidity
United States
Functional performance
Diabetes Mellitus
Type 2
Musculoskeletal
Geriatrics and Gerontology
business
Body mass index
human activities
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Haan, MN; Lee, A; Odden, MC; Aiello, AE; To, TM; & Neuhaus, JM. (2016). Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 71(8), 1089-1095. doi: 10.1093/gerona/glw014. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1qs4q63g
The journals of gerontology. Series A, Biological sciences and medical sciences, vol 71, iss 8
Popis: BackgroundComorbidity (COM) is an important issue in aging. Cardiovascular disease (CVD) and osteoarthritis separately and together may modify the trajectories of functional decline. This analysis examines whether specific and unrelated COMs influence functional change differently and vary by gender.MethodsA cohort study of 1,789 (aged 60 years and older) Mexican Americans was followed annually for up to 10 years. We created four groups of COM (CVD alone, lower body osteoarthritis alone [OA], neither, or both). We employed mixed effects Poisson models with Instrumental Activities of Daily Living (IADL) as the outcome. We tested whether the association between COM and decline in functional status differed by gender.ResultsIADL impairments in those with CVD, OA, or both were significantly higher at baseline and increased more rapidly over time compared to those with neither condition. Compared to women with no COM, the number of IADL impairments in women with CVD alone were 1.36 times greater, with OA were 1.35 times greater, and both conditions were 1.26 times greater. Compared to men with no COM, IADL impairments in men with CVD alone were 1.15 times greater, OA alone were 1.12 times greater, and both were 1.26 times greater.ConclusionsOver time, the influence of COM on functional decline differs by specific combinations of COM and by gender. Aggregate COM scales obscure the biological and temporal heterogeneity in the effects of COM. Time-dependent-specific COMs better assess the development of impairment. Women experience a higher burden of functional impairment due to COM than men.
Databáze: OpenAIRE
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