CD14, a novel surface marker of esophageal cancer stem cells
| Autor: | Yonggang, Lin, Jianjiang, Dong, Wei, Yu, Yufei, Li, Zhixin, Liu, Jiaqi, Liu, Cuiju, Wang, Jian, Qin, Liting, Zhu, Jun, Liang |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Oncology Reports. 49 |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2022.8450 |
| Popis: | Studies on targeting cancer stem cells (CSCs) have not yielded satisfactory results regarding solid tumor treatments; one of the reasons for this is the difficulty associated with the identification of a relatively specific antigen in solid tumors. CD14, which is mainly expressed in certain immune cells, is associated with tumor recurrence, growth, metastasis and resistance to treatment, which is in conformity with the characteristics of CSCs. It was thus hypothesized that esophageal CSCs (ECSCs) express CD14. In the present study, paraffin‑embedded sections of human esophageal carcinoma were used to determine the co‑expression of CD14 and the ECSC marker aldehyde dehydrogenase‑1 (ALDH1) using immunofluorescence. CD14 |
| Databáze: | OpenAIRE |
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