Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues
Autor: | Abdulahad Dogan, Fatih Donmez |
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Rok vydání: | 2021 |
Předmět: |
Antioxidant
Adenosine Deaminase Health Toxicology and Mutagenesis medicine.medical_treatment Moxifloxacin Levofloxacin Pharmacology Toxicology Antioxidants Lipid peroxidation Superoxide dismutase Nalidixic Acid chemistry.chemical_compound Ciprofloxacin Malondialdehyde medicine Animals Aspartate Aminotransferases Rats Wistar Triglycerides Peroxidase chemistry.chemical_classification Glutathione Peroxidase Chemical Health and Safety biology SARS-CoV-2 Superoxide Dismutase Chemistry Glutathione peroxidase Public Health Environmental and Occupational Health COVID-19 General Medicine Glutathione Catalase Rats Oxidative Stress Glucose Creatinine Myeloperoxidase biology.protein Lipid Peroxidation Fluoroquinolones medicine.drug |
Zdroj: | Drug and Chemical Toxicology. 45:2686-2698 |
ISSN: | 1525-6014 0148-0545 |
Popis: | Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixicacid. FQs are used against SARS-CoV-2 in our country, and for the treatment of some urinary tract diseases, gastrointestinal diseases, respiratory tract diseases, sexually transmitted diseases, and dermatological diseases. The present study investigated the effect of 1-,7-,14-day treatments of three differentFQ derivatives; ciprofloxacin (CIP) 80 mg/kg/day, levofloxacin (LVX) 40 mg/kg/day, and moxifloxacin(MXF) 40mg/kg/day, on biochemical parameters, lipid peroxidation, antioxidant enzymes, and immunotoxicity. 72 Wistar albino male rats were distributed to four groups including 18 rats in each group and were sacrificed on three different time points. The 14-day treatment of MXF significantly reduced the levels of aspartate aminotransferase (AST), glucose, reduced glutathione (GSH), malondialdehyde (MDA), catalase (CAT), myeloperoxidase (MPO), adenosine deaminase (ADA), and glutathione peroxidase (GPx). Furthermore, 14-day treatment of LVX increased liver [GSH, MPO, ADA, superoxide dismutase (SOD)], and GSH (erythrocyte) levels; whereas it significantly reduced the levels of AST, TG (triglycerides) and associated parameters levels in all the tissues (MDA), erythrocytes, and liver (MPO, CAT, SOD, GPx). After 14-day treatment of CIP; the erythrocyte levels of GSH, MPO, GPx, and CAT significantly decreased; whereas the levels of glucose, creatinine, MPO (liver), and GST (kidney and erythrocyte) significantly increased. It has been concluded that FQ derivatives used in this experiment did not display any correlation in terms of the efficacies in the different time points and tissues. Thus, it is recommended to use such FQ derivatives considering the duration of use and target tissue. |
Databáze: | OpenAIRE |
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