Moderate Amounts of Vitamin D3 in Supplements are Effective in Raising Serum 25-Hydroxyvitamin D from Low Baseline Levels in Adults: A Systematic Review
| Autor: | Jean-Philippe Bonjour, Flore Dontot Payen, Susan J. Whiting, Brigitte Rousseau |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Vitamin
medicine.medical_specialty Fortification fortification Vitamin D status lcsh:TX341-641 vitamin D deficiency supplements chemistry.chemical_compound Bolus (medicine) Internal medicine adults medicine Vitamin D and neurology Adults Humans Supplements Vitamin D Fortified Food Cholecalciferol Randomized Controlled Trials as Topic ddc:616 Nutrition and Dietetics Dose-Response Relationship Drug business.industry Communication Vitamin D Deficiency medicine.disease 25-hydroxyvitamin D vitamin D status Dose–response relationship Endocrinology chemistry ddc:618.97 Dietary Supplements Food Fortified Multivitamin business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 7, Iss 4, Pp 2311-2323 (2015) Nutrients Nutrients, Vol. 7 (2015) pp. 2311-2323 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu7042311 |
| Popis: | There is controversy surrounding the designation of vitamin D adequacy as defined by circulating levels of the metabolite 25-hydroxyvitamin D (25(OH)D). Depending on the cutoff level chosen, dietary intakes of vitamin D may or may not provide sufficient impact upon vitamin D status measured as improvement in serum levels of 25(OH)D. We sought to examine whether modest daily doses (5–20 μg) as found in fortified foods or multivitamin supplements had a measureable impact on vitamin D status, defined as moving from below to above 50 nmol/L, or from less than 30 nmol/L to above 30 nmol/L. Published literature was searched for relevant articles describing randomized controlled trials. Exclusion criteria were: studies not involving humans; review articles; studies lacking blood level data pre- and post-treatment; no control group; bolus treatments (weekly, monthly, yearly); vitamin D 20 μg; baseline 25(OH)D ≥75 nmol/L; subjects not defined as healthy; studies 50 nmol/L) or from “deficient” (30 but |
| Databáze: | OpenAIRE |
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