[Modulation of Host Immune System by Staphylococcal Superantigen-like (SSL) Proteins]
| Autor: | Tsutomu Tsuji |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Staphylococcus aureus
Bacterial Toxins Pharmaceutical Science Exotoxins chemical and pharmacologic phenomena Enterotoxin medicine.disease_cause Microbiology Immunomodulation Enterotoxins Mice Immune system medicine Superantigen Leukocytes Animals Humans Receptor Pathogen Blood Coagulation Pharmacology Superantigens biology Toxic shock syndrome Staphylococcal Infections medicine.disease Immune System biology.protein Antibody |
| Zdroj: | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 141(4) |
| ISSN: | 1347-5231 |
| Popis: | Staphylococcus aureus is a common pathogen causing a wide range of infectious diseases in humans and animals. This bacterium secretes a variety of exoproteins, including toxins known as superantigens, such as toxic shock syndrome toxin-1 (TSST-1) and enterotoxins. Staphylococcal superantigen-like (SSL) proteins are a family of exoproteins showing structural similarities with superantigens but no superantigenic activity. This family is composed of 14 members (SSL1-SSL14), and recent studies have revealed that these members exhibit various immunomodulatory activities: e.g., inhibition of antibody and complement functions, impairment of leukocyte trafficking, modulation of receptor functions, inappropriate activation of immunocytes, and inhibition of blood coagulation. These activities have been proposed to contribute to immune evasion of the bacteria. The interactions between SSL proteins and their target molecules in the host immune system and the pathophysiological roles of SSL proteins in the bacterial infections are reviewed in this article. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|