The effect of valproic acid on SCE and chromosome aberrations in epileptic children
| Autor: | Bingqing Lu, Xuefen Lu, Youqi Huang, Lingjia Hu |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Time Factors Adolescent Lymphocyte Sister chromatid exchange Biology Epilepsy Internal medicine medicine Humans Lymphocytes Child Chromosome Aberrations Genetics Valproic Acid Dose-Response Relationship Drug Mutagenicity Tests Matched control Infant Chromosome General Medicine medicine.disease medicine.anatomical_structure Endocrinology Child Preschool lipids (amino acids peptides and proteins) Sister Chromatid Exchange medicine.drug |
| Zdroj: | Mutation Research Letters. 243:63-66 |
| ISSN: | 0165-7992 |
| DOI: | 10.1016/0165-7992(90)90124-3 |
| Popis: | Sister-chromatid exchange (SCE) and chromosome aberrations have been studied in peripheral lymphocytes of 20 epileptic children treated in monotherapy with valproic acid (VPA) for 6-52 months and in 2 matched control groups. The frequencies of SCE in the VPA-treated epileptic children were significantly higher than in the 2 control groups (p less than 0.01); rates of chromosome aberrations were slightly higher but not significantly different from the 2 control groups. We also examined SCE in 10 epileptic children before and after they took sodium valproate for 6-7 months; there was a statistically significant change in SCE following VPA. 9 normal children whose lymphocytes were exposed in vitro to sodium valproate (5-20 micrograms/ml) showed a significant increase in SCE. |
| Databáze: | OpenAIRE |
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